file:interpro/panther/PTHR24356/PTHR24356-review.md

PANTHER family review PTHR24356: IBA propagation assessment for sid2

Gene Ontology annotation through association of InterPro records with GO terms

Annotation inferences using phylogenetic trees

Gene Ontology annotation based on UniProtKB/Swiss-Prot Subcellular Location vocabulary mapping, accompanied by conservative changes to GO terms applied by UniProt

GO_REF:0000116

Automatic Gene Ontology annotation based on Rhea mapping

GO_REF:0000117

Electronic Gene Ontology annotations created by ARBA machine learning models

GO_REF:0000120

Combined Automated Annotation using Multiple IEA Methods

PMID:10459013

Sid2p, a spindle pole body kinase that regulates the onset of cytokinesis.

The Sid2-GFP reporter was observed at SPBs throughout the cell cycle and transiently at the division site during ring constriction and septation; its kinase activity peaks at septation and depends on all other SIN genes.

PMID:10769201

The S. pombe orthologue of the S. cerevisiae mob1 gene is essential and functions in signalling the onset of septum formation.

Mob1 co-precipitates with Sid2, defining the Sid2-Mob1 complex.

PMID:10837231

Mob1p interacts with the Sid2p kinase and is required for cytokinesis in fission yeast.

Mob1-Sid2 is required for initiation of cytokinesis but not for mitotic exit, distinguishing the SIN from the budding-yeast MEN.

PMID:15060149

Initiation of cytokinesis is controlled through multiple modes of regulation of the Sid2p-Mob1p kinase complex.

Mob1 is required for both Sid2 SPB localization and Sid2 kinase activity; activating phosphorylation occurs at Ser402 and Thr578.

PMID:16085489

The 14-3-3 protein rad24p modulates function of the cdc14p family phosphatase clp1p/flp1p in fission yeast.

SIN-dependent (Sid2-dependent) cytoplasmic retention of Clp1 via Rad24 underlies the cytokinesis checkpoint.

PMID:16787941

The Schizosaccharomyces pombe septation initiation network (SIN) is required for spore formation in meiosis.

SIN proteins, including Sid2, localize to the SPB in meiosis and are required for spore formation.

PMID:16823372

ORFeome cloning and global analysis of protein localization in the fission yeast Schizosaccharomyces pombe.

Genome-wide YFP localization places Sid2 at the SPB.

PMID:18951025

The SIN kinase Sid2 regulates cytoplasmic retention of the S. pombe Cdc14-like phosphatase Clp1.

Sid2 directly phosphorylates Clp1, creating Rad24 binding sites that keep Clp1 in the cytoplasm in late mitosis.

PMID:20805322

The mitosis-to-interphase transition is coordinated by cross talk between the SIN and MOR pathways in Schizosaccharomyces pombe.

The SIN (via Sid2) inhibits MOR signaling in mitosis, coordinating actin/cytoskeletal remodeling at the mitosis-to-interphase transition.

PMID:20876564

Antagonistic roles of PP2A-Pab1 and Etd1 in the control of cytokinesis in fission yeast.

Two-hybrid assays show the PP2A B-subunit Pab1 interacts with Sid2 (and other SIN components).

PMID:22419817

The fission yeast septation initiation network (SIN) kinase, Sid2, is required for SIN asymmetry and regulates the SIN scaffold, Cdc11.

Sid2 phosphorylates Cdc11 in a positive-feedback loop required for SIN asymmetry and maximal anaphase signaling.

PMID:22684255

The S. pombe cytokinesis NDR kinase Sid2 activates Fin1 NIMA kinase to control mitotic commitment through Pom1/Wee1.

In G2, Sid2-Mob1 acts independently of the SIN to directly activate Fin1, modulating mitotic commitment via Pom1/Cdr1/Cdr2-Wee1.

PMID:23087209

The kinesin-14 Klp2 is negatively regulated by the SIN for proper spindle elongation and telophase nuclear positioning.

Sid2 phosphorylates Klp2 at S113/S123, inhibiting its microtubule recruitment and promoting anaphase spindle elongation and nuclear positioning during delayed cytokinesis.

PMID:23394829

Identification of SIN pathway targets reveals mechanisms of crosstalk between NDR kinase pathways.

A proteomics screen identified multiple Sid2 substrates including MOR components Nak1 and Sog2, defining SIN-MOR crosstalk.

PMID:24115772

SIN-dependent phosphoinhibition of formin multimerization controls fission yeast cytokinesis.

Sid2 phosphorylates the formin Cdc12 to abrogate its multimerization/F-actin bundling, controlling contractile ring assembly and maintenance.

PMID:24790095

Characterization of the roles of Blt1p in fission yeast cytokinesis.

Blt1p contributes to Sid2/Mob1 recruitment and contractile-ring constriction during cytokinesis.

PMID:24972934

Cross talk between NDR kinase pathways coordinates cytokinesis with cell separation in Schizosaccharomyces pombe.

Sid2 phosphorylation of Nak1 inhibits the MOR during cytokinesis, preventing premature cell separation and lysis.

PMID:25501814

The septation initiation network controls the assembly of nodes containing Cdr2p for cytokinesis in fission yeast.

SIN (Sid2) activity is necessary and sufficient to disperse type-1 node proteins Cdr2p and Mid1p into the cytoplasm.

PMID:28914606

Nanoscale architecture of the Schizosaccharomyces pombe contractile ring.

Sid2 localizes to the intermediate (80-160 nm) accessory-protein layer of the contractile ring.

PMID:29813053

Specific detection of fission yeast primary septum reveals septum and cleavage furrow ingression during early anaphase independent of mitosis completion.

Primary septum and furrow ingression begin during early anaphase, consistent with SIN/Sid2-driven septum biogenesis.

PMID:30853434

NDR Kinase Sid2 Drives Anillin-like Mid1 from the Membrane to Promote Cytokinesis and Medial Division Site Placement.

Sid2 phosphorylates Mid1 to remove it from the cortex at ring-constriction onset, promoting cytokinesis and medial division-site placement.

PMID:31041892

Fission yeast type 2 node proteins Blt1p and Gef2p cooperate to ensure timely completion of cytokinesis.

Sid2 localizes to the contractile ring to promote constriction, septation and cell division; its recruitment depends on type-2 node proteins Blt1p and Gef2p.