Sec71 (Drosophila melanogaster, Q9VJW1, CG7578, FBgn0028538): manual literature research Manual

Sec71 (Drosophila melanogaster, Q9VJW1, CG7578, FBgn0028538): manual literature research

No deep-research API was available for this review. This summary was compiled by hand
from PubMed searches ("Sec71 AND Drosophila", 7 hits) and the cached publications in
publications/. Quotes are verbatim from the cached files.

Identity and family

Sec71 is the single fly member of the BIG1/BIG2 (ARFGEF1/2) subfamily of large
Sec7-domain Arf GEFs PMID:22291037.
UniProt Q9VJW1 (TrEMBL, 1653 aa) carries Pfam DCB, Sec7-like_HUS, Sec7, Sec7-like_HDS and
BIG2_C, with the SEC7 domain at 575-765 (PROSITE PS50190). No transmembrane segment is
predicted (Sec71-bioinformatics/RESULTS.md).
The name is shared with yeast Sec71, which is Sec66, a small single-pass subunit of the
Sec63 translocon complex; the two proteins are unrelated (Sec71-bioinformatics/RESULTS.md).

Molecular function: Arf1 GEF

PMID:28420712 (abstract only in cache)
PMID:28420712

Recruitment by Arl1 to the trans-Golgi

PMID:22291037
PMID:22291037
PMID:22291037
Purified Sec71(N-453) binds Arl1-GTP liposomes directly; the C-terminal region is cytosolic.

Golgi structure and brefeldin A

PMID:33262309 (abstract only)

Secretory trafficking

PMID:31649044

Downstream developmental roles (phenotypes)

Dendrite pruning: PMID:28420712
Endocytosis of Neuroglian: PMID:28420712
Neural stem cell reactivation (PMID:37567172, abstract) and neuroblast polarity:
PMID:40208939

These phenotypes follow from the general Golgi/Arf1 function and are not treated as core
processes.