An antibiotic factory caught in action.
-
In type II PKSs the polyketide chain is polymerized by the heterodimeric ketosynthase-chain length factor (KS-CLF); KS carries the catalytic activity.
"In type II polyketide synthases (PKSs), chains are polymerized by the heterodimeric ketosynthase-chain length factor (KS-CLF)."
-
The KS subunit catalyzes chain initiation and elongation; CLF regulates chain length but has no active site.
"Although CLF regulates chain length, it does not have an active site; KS must catalyze both chain initiation and elongation."
actI-ORF1 review notes (BGC project) with predicted-complex evidence
Gene Ontology annotation through association of InterPro records with GO terms
Annotation inferences using phylogenetic trees
Gene Ontology annotation based on Ensembl/EnsemblGenomes orthology
Combined Automated Annotation using Multiple Source Sequence Analysis