BMP9 is synthesized as a precursor and its mature ligand can remain associated with a prodomain. The observed 4YCG complex contains human mature ligand and a mouse prodomain; this mixed-species structure is not an entirely human precursor experiment. PMID:25751889(https://pubmed.ncbi.nlm.nih.gov/25751889/)
Context-dependent vascular responses justify retaining positive and negative regulatory annotations separately. PMID:17068149(https://pubmed.ncbi.nlm.nih.gov/17068149/), PMID:20406889(https://pubmed.ncbi.nlm.nih.gov/20406889/)
Joint Gdf2/Bmp10 physiology does not isolate GDF2-specific intracellular iron handling. PMID:39453386(https://pubmed.ncbi.nlm.nih.gov/39453386/)
Barrier improvement leaves junction-assembly specificity unresolved. PMID:32561494(https://pubmed.ncbi.nlm.nih.gov/32561494/)
The source guide keeps construct, assay, erratum and target-identification limits next to primary locators. The evidence archive preserves literal contexts and the partial nature of flat projections from OR expressions.
Direct binding to ALK1 supports mature BMP9 receptor recognition; receptor-domain NMR and docking remain distinct evidence. Covalent and noncovalent solution dimers retain signaling activity but differ in persistence and proteolytic susceptibility. These biochemical states do not establish additional natural splice products or endogenous clearance rates. PMID:22799562(https://pubmed.ncbi.nlm.nih.gov/22799562/); PMID:25237187(https://pubmed.ncbi.nlm.nih.gov/25237187/).
Direct ligand–ALK1 binding and receptor-mediated SMAD responses describe one extracellular signaling unit. PMID:22799562(https://pubmed.ncbi.nlm.nih.gov/22799562/); PMID:17068149(https://pubmed.ncbi.nlm.nih.gov/17068149/). Endothelial DNA-synthesis regulation does not make BMP9 replication machinery. PMID:19366699(https://pubmed.ncbi.nlm.nih.gov/19366699/). Iron attribution and junction assembly remain narrower unresolved questions despite positive physiological and barrier responses. PMID:39453386(https://pubmed.ncbi.nlm.nih.gov/39453386/); PMID:32561494(https://pubmed.ncbi.nlm.nih.gov/32561494/).
The current YAML archive succeeds the unchanged historical JSON linked above. The source guide identifies the assays and the 4YCG description/sequence discrepancy.
BMP9 receptor recognition initiates cytokine signaling; it is not a second, independent core function. PMID:17068149(https://pubmed.ncbi.nlm.nih.gov/17068149/); PMID:22799562(https://pubmed.ncbi.nlm.nih.gov/22799562/). Opposing vascular outcomes remain dependent on tissue and assay context. PMID:18309101(https://pubmed.ncbi.nlm.nih.gov/18309101/); PMID:20406889(https://pubmed.ncbi.nlm.nih.gov/20406889/). The current YAML archive and source guide govern the present interpretation; the earlier JSON link records the original historical snapshot.