Mdh1 (CG5362, Q9VKX2) notes

Module: dmel_citrate_malate_shuttle (with Acly, sea); malate-aspartate shuttle partner of Got1.

Literature journal

• Cytoplasmic vs mitochondrial MDH separation and allozyme kinetics PMID:45555
• Null mutants PMID:109448
• Ethanol tolerance PMID:19033156; PMID:19033156
• Peroxisome ISM from Faust 2012 inventory PMID:22758915; C-terminus ...SNL.
• Deep research (falcon) agrees: cytosolic MDH; mitochondrial isozyme is Mdh2.

Decisions

• TCA cycle IBA: MARK_AS_OVER_ANNOTATED (compartment mismatch; propagation_review added).
• Peroxisome ISM: UNDECIDED. Gluconeogenesis ISS: KEEP_AS_NON_CORE. catalytic activity IEA: MODIFY.