PMID:21192796

Pseudomonas aeruginosa β-lactamase induction requires two permeases, AmpG and AmpP.

PhoA/LacZ fusions show AmpP is an inner-membrane protein with 10 TM helices.

"AmpP fusions at amino acids 80, 170, 248, 308, 400 as well as full length were LacZ-positive and PhoA-negative, and fusions at amino acids 38, 120, 195, 278, and 360 were LacZ-negative and PhoA-positive, consistent with 10 TM domains (Figures 4A and 4B)."
Benzylpenicillin induction of the ampC promoter is lost in ampP and ampG mutants.

"Benzyl-penicillin dependent induction of PampC-lacZ was lost in PAOampG or PAOampP (Figure 6)."

PMID:20713660

ampG gene of Pseudomonas aeruginosa and its role in β-lactamase expression.

ampGh1 (PA4218) deletion has little effect on beta-lactam resistance and does not complement ampG mutants.

"resistance while ampGh1 deletion had little effect on the resistance"

file:PSEAE/PA4218/PA4218-uniprot.txt

UniProt entry Q9HWG8

PA4218 is in the RhtX/FptX siderophore transporter subfamily.

"NCBIfam; TIGR02718; sider_RhtX_FptX; 1."
PA4218 matches the MFS transporter signature.

"InterPro; IPR011701; MFS."

GO_REF:0000002

Gene Ontology annotation through association of InterPro records with GO terms

GO_REF:0000033

Annotation inferences using phylogenetic trees

GO_REF:0000044

Gene Ontology annotation based on UniProtKB/Swiss-Prot Subcellular Location vocabulary mapping, accompanied by conservative changes to GO terms applied by UniProt.