Manual transfer of experimentally-verified manual GO annotation data to orthologs by curator judgment of sequence similarity
Annotation inferences using phylogenetic trees
Gene Ontology annotation based on UniProtKB/Swiss-Prot Subcellular Location vocabulary mapping, accompanied by conservative changes to GO terms applied by UniProt
Automatic transfer of experimentally verified manual GO annotation data to orthologs using Ensembl Compara
The zinc finger protein A20 interacts with a novel anti-apoptotic protein which is cleaved by specific caspases.
T6BP, a TRAF6-interacting protein involved in IL-1 signaling.
Chromosome 13q12 encoded Rho GTPase activating protein suppresses growth of breast carcinoma cells, and yeast two-hybrid screen shows its interaction with several proteins.
Functional proteomics mapping of a human signaling pathway.
A20 is a potent inhibitor of TLR3- and Sendai virus-induced activation of NF-kappaB and ISRE and IFN-beta promoter.
Essential role for TAX1BP1 in the termination of TNF-alpha-, IL-1- and LPS-mediated NF-kappaB and JNK signaling.
Inflammatory cardiac valvulitis in TAX1BP1-deficient mice through selective NF-kappaB activation.
Proteomic analysis of exosomes from human neural stem cells by flow field-flow fractionation and nanoflow liquid chromatography-tandem mass spectrometry.
The Autophagy Receptor TAX1BP1 and the Molecular Motor Myosin VI Are Required for Clearance of Salmonella Typhimurium by Autophagy.
Mechanistic Insights into Recognitions of Ubiquitin and Myosin VI by Autophagy Receptor TAX1BP1.
Mechanistic insights into the interactions of NAP1 with the SKICH domains of NDP52 and TAX1BP1.
The ubiquitin-editing enzyme A20 requires RNF11 to downregulate NF-kappaB signalling.
The kinase IKKα inhibits activation of the transcription factor NF-κB by phosphorylating the regulatory molecule TAX1BP1.
Toward an understanding of the protein interaction network of the human liver.
A proteome-scale map of the human interactome network.
Widespread Expansion of Protein Interaction Capabilities by Alternative Splicing.
TAX1BP1 Restrains Virus-Induced Apoptosis by Facilitating Itch-Mediated Degradation of the Mitochondrial Adaptor MAVS.
TRIM32-TAX1BP1-dependent selective autophagic degradation of TRIF negatively regulates TLR3/4-mediated innate immune responses.
An interactome perturbation framework prioritizes damaging missense mutations for developmental disorders.
A protein-protein interaction map of the TNF-induced NF-κB signal transduction pathway.
Autophagy Promotes Infectious Particle Production of Mopeia and Lassa Viruses.
Extensive disruption of protein interactions by genetic variants across the allele frequency spectrum in human populations.
A reference map of the human binary protein interactome.
Interactome Mapping Provides a Network of Neurodegenerative Disease Proteins and Uncovers Widespread Protein Aggregation in Affected Brains.
Receptor-mediated clustering of FIP200 bypasses the role of LC3 lipidation in autophagy.
Dual proteome-scale networks reveal cell-specific remodeling of the human interactome.
Reconstitution defines the roles of p62, NBR1 and TAX1BP1 in ubiquitin condensate formation and autophagy initiation.
TAX1BP1:TNFAIP3(A20) binds RIPK1-containing complexes
TNFAIP3 (A20) ubiquitinates RIPK1 with K48-linked Ub chains
TAX1BP1:A20 inhibit TBK1/IKKi K63-polyubiquitination
Manual literature notes for TAX1BP1 PN/autophagy review
OpenAI focused deep research for TAX1BP1 proteostasis review
Manual deep research fallback for TAX1BP1 PN review
Falcon (Edison) deep research for TAX1BP1 functional annotation
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TAX1BP1 is a ubiquitin-directed selective-autophagy cargo receptor that uses two C-terminal UBZ (ubiquitin-binding zinc finger) domains, the SKICH domain, and LC3-interacting regions to route ubiquitylated cargo to lysosomal degradation; the second UBZ is essential for ubiquitin binding and prefers K63-linked chains while also binding linear tetra-ubiquitin and K48-linked chains.
"...Two C-terminal UBZ (ubiquitin-binding zinc finger) domains... in TAX1BP1; the cited discussion emphasizes that the ...second UBZ... is essential for ubiquitin binding and shows preference for ...K63-linked ubiquitin chains..., can bind ...linear tetra-ubiquitin..., and (unlike OPTN/NDP52 in that discussion) TAX1BP1 can also bind ...K48-linked... chains."
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TAX1BP1 functions as an aggrephagy receptor that promotes clearance of MAVS aggregates via an ATG8-family-protein-dependent pathway, thereby attenuating downstream innate immune (IFN/NF-kappaB) signaling.
"A concrete mechanistic example is ...MAVS aggrephagy...: TAX1BP1 functions as an aggrephagy receptor promoting ...MAVS aggregate clearance..., which directly reduces downstream innate immune signaling."
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Phosphorylation of TAX1BP1 by the antiviral kinases TBK1 and IKBKE/IKKi promotes its lysosomal localization and receptor function; infection can also route TAX1BP1 to lysosomes through an ATG8-family-independent mechanism requiring RB1CC1/FIP200.
"...TBK1 and IKBKE/IKKi... redundantly phosphorylate TAX1BP1...Phosphorylation promotes TAX1BP1 ...lysosomal localization... and influences its receptor function...TAX1BP1 is required for clearance of MAVS aggregates via an ...ATG8-family protein-dependent... pathway; infection conditions can also route TAX1BP1 to lysosomes through an ATG8-family-independent mechanism requiring ...RB1CC1/FIP200...."
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TAX1BP1 is reported to be sufficient to promote lysophagy (selective autophagy of damaged lysosomes).
"In lysophagy-focused discussion, TAX1BP1 is specifically reported as ...sufficient to promote lysophagy... (selective autophagy of damaged lysosomes)."
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A 2024 cryo-EM study of myosin VI lists TAX1BP1 among myosin VI cargo adapter proteins, with myosin VI binding the autophagy receptors NDP52, TAX1BP1, and Optineurin via its cargo-binding domains.
"A 2024 Nature Communications cryo-EM study of ...myosin VI... explicitly lists TAX1BP1 among myosin VI cargo adapter proteins and notes myosin VI binding to autophagy receptors including ...NDP52, TAX1BP1, and Optineurin... via myosin VI cargo-binding domains."
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Later work implicates TAX1BP1 in negative-feedback regulation of STING signaling via TAX1BP1-directed golgiphagy, extending its role in restraining innate immune signaling to the Golgi compartment.
"Later work also implicates TAX1BP1 in ...Golgi-associated autophagic regulation..."
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TAX1BP1 acts mainly in the cytosol and at selective-autophagy compartments, including autophagosomes/autophagic vacuoles, the outer autophagosome membrane, and lysosomes (increased LAMP1 colocalization when phosphorylated).
"TAX1BP1 acts mainly in the ...cytosol... and at sites of selective autophagy cargo capture, with evidence for localization to ...autophagosomes/autophagic vacuoles..., ...lysosomes... (including increased LAMP1 colocalization when phosphorylated), and likely the ...outer autophagosome membrane... through ubiquitin/myosin VI coupling."