CDH1 (E-cadherin) — curation notes

2026-06-22 — manual PubMed curation of IBA support

Applied the proven manual-PubMed support-finding workflow (asta deprecated, see issue #1599) to the
14 IBA annotations that lacked independent PMID/DOI support. Several already had a supported_by
entry pointing at the falcon deep-research file (file:...), which is why they were flagged
unsupported — I appended foundational primary PMIDs (verified verbatim against the fetched abstract).

Added independent PMID support to 8 of 14 IBA annotations:

Term	GO	Reference
beta-catenin binding	GO:0008013	PMID:7806582 (β-catenin interacts with E-cadherin)
catenin complex	GO:0016342	PMID:2349235 (uvomorulin/E-cadherin associates with catenins α/β/γ)
cadherin binding	GO:0045296	PMID:20190754 (classical-cadherin strand-swap homophilic binding)
cell-cell adhesion mediated by cadherin	GO:0044331	PMID:3498123 (Nagafuchi/Takeichi 1987)
calcium-dependent cell-cell adhesion	GO:0016339	PMID:3498123 ("Ca2+-dependent intercellular adhesion between epithelial cells")
adherens junction	GO:0005912	PMID:7806582 (E-cadherin in adherens junctions of epithelia)
adherens junction organization	GO:0034332	PMID:3498123 (anti-E-cadherin disperses compact cell colonies)
apical junction complex	GO:0043296	PMID:23643492 (E-cadherin at the epithelial zonula adherens)

Left unsupported (6) — honest:

GO:0007043 cell-cell junction assembly — core E-cadherin function, but I did not locate a clean
cached primary statement specifically about junction assembly in a quick search (Adams/Vasioukhin
live-imaging papers would fit; not fetched). Distinct from the organization term above.
GO:0016477 cell migration — real but context-dependent (E-cadherin suppresses single-cell
invasion yet enables collective migration); a single IBA "cell migration" is too coarse to anchor
cleanly to one primary paper.
GO:0000902 cell morphogenesis — broad developmental term; better captured by specific
morphogenesis processes than a general primary citation.
GO:0005737 cytoplasm — E-cadherin is a plasma-membrane protein with a cytoplasmic domain;
a blanket "cytoplasm" CC is arguably an over-annotation and was not given primary support.
GO:0007416 synapse assembly — the synaptic classical cadherin is largely N-cadherin (CDH2);
this looks like a phylogenetic over-propagation to CDH1 and was not supported.
GO:0016600 flotillin complex — obscure CC; no clean primary support surfaced; likely
over-propagated.

Note: unlike the LGALS3 asta run, CDH1's foundational literature (Nagafuchi/Takeichi 1987, the
Ozawa/Kemler catenin papers, Harrison 2010 structure) was trivially recovered by direct PubMed
search — again reinforcing that targeted manual search beats the retrieval-only provider.