Manual transfer of experimentally-verified manual GO annotation data to orthologs by curator judgment of sequence similarity
Annotation inferences using phylogenetic trees
Gene Ontology annotation based on UniProtKB/Swiss-Prot Subcellular Location vocabulary mapping, accompanied by conservative changes to GO terms applied by UniProt
Gene Ontology annotation based on curation of immunofluorescence data
Automatic transfer of experimentally verified manual GO annotation data to orthologs using Ensembl Compara
Electronic Gene Ontology annotations created by ARBA machine learning models
Combined Automated Annotation using Multiple IEA Methods
Eotaxin activates T cells to chemotaxis and adhesion only if induced to express CCR3 by IL-2 together with IL-4.
Thrombospondin-1 acts via IAP/CD47 to synergize with collagen in alpha2beta1-mediated platelet activation.
A novel protease-docking function of integrin at invadopodia.
Activation of EphA2 kinase suppresses integrin function and causes focal-adhesion-kinase dephosphorylation.
Effect of medium change on the development of in vitro matured and fertilized bovine oocytes cultured in medium containing amino acids.
Conformation, localization, and integrin binding of talin depend on its interaction with phosphoinositides.
Fibulin-1 suppression of fibronectin-regulated cell adhesion and motility.
The integrin cytoplasmic domain-associated protein ICAP-1 binds and regulates Rho family GTPases during cell spreading.
Integrin cytoplasmic domain-associated protein 1alpha (ICAP-1alpha ) interacts directly with the metastasis suppressor nm23-H2, and both proteins are targeted to newly formed cell adhesion sites upon integrin engagement.
The LIM protein Ajuba is recruited to cadherin-dependent cell junctions through an association with alpha-catenin.
Disruption of focal adhesions by integrin cytoplasmic domain-associated protein-1 alpha.
The integrin beta1 subunit cytoplasmic tail forms oligomers: a potential role in beta1 integrin clustering.
Epstein-Barr virus infection of polarized tongue and nasopharyngeal epithelial cells.
CCN3 (NOV) is a novel angiogenic regulator of the CCN protein family.
Ganglioside GM3 inhibits matrix metalloproteinase-9 activation and disrupts its association with integrin.
Tetraspanins CD9 and CD81 function to prevent the fusion of mononuclear phagocytes.
Cell adhesion to fibrillin-1 molecules and microfibrils is mediated by alpha 5 beta 1 and alpha v beta 3 integrins.
JAML, a novel protein with characteristics of a junctional adhesion molecule, is induced during differentiation of myeloid leukemia cells.
Association of the calpain/calpastatin network with subcellular organelles.
Involvement of transmembrane domain interactions in signal transduction by alpha/beta integrins.
Integrin alpha5beta1 and ADAM-17 interact in vitro and co-localize in migrating HeLa cells.
A mitochondrial protein, Bit1, mediates apoptosis regulated by integrins and Groucho/TLE corepressors.
Selective modulation of type 1 insulin-like growth factor receptor signaling and functions by beta1 integrins.
A family of beta 7 integrins on human mucosal lymphocytes.
alpha4beta1- and alpha6beta1-integrins are functional receptors for midkine, a heparin-binding growth factor.
Nuclear translocation of integrin cytoplasmic domain-associated protein 1 stimulates cellular proliferation.
The Z-disc proteins myotilin and FATZ-1 interact with each other and are connected to the sarcolemma via muscle-specific filamins.
Murine lipid phosphate phosphohydrolase-3 acts as a cell-associated integrin ligand.
Phosphorylation of ACAP1 by Akt regulates the stimulation-dependent recycling of integrin beta1 to control cell migration.
Collagen XVI harbors an integrin alpha1 beta1 recognition site in its C-terminal domains.
Small GTPase Rab21 regulates cell adhesion and controls endosomal traffic of beta1-integrins.
Role of dystrophins and utrophins in platelet adhesion process.
Alpha9beta1: a novel osteoclast integrin that regulates osteoclast formation and function.
Proteomic and bioinformatic characterization of the biogenesis and function of melanosomes.
alphaVbeta6 is a novel receptor for human fibrillin-1. Comparative studies of molecular determinants underlying integrin-rgd affinity and specificity.
Vascular cell adhesion molecule-1 and the integrin VLA-4 mediate adhesion of human B cell precursors to cultured bone marrow adherent cells.
Structure of three tandem filamin domains reveals auto-inhibition of ligand binding.
Role of ADAM-9 disintegrin-cysteine-rich domains in human keratinocyte migration.
Rab25 associates with alpha5beta1 integrin to promote invasive migration in 3D microenvironments.
Interaction of integrin beta1 with cytokeratin 1 in neuroblastoma NMB7 cells.
Regulation of endothelial cell cytoskeletal reorganization by a secreted frizzled-related protein-1 and frizzled 4- and frizzled 7-dependent pathway: role in neovessel formation.
Filamin A regulates cell spreading and survival via beta1 integrins.
CCL25 and CCL28 promote alpha4 beta7-integrin-dependent adhesion of lymphocytes to MAdCAM-1 under shear flow.
Large-scale proteomics and phosphoproteomics of urinary exosomes.
An unrecognized extracellular function for an intracellular adapter protein released from the cytoplasm into the tumor microenvironment.
A point mutation in KINDLIN3 ablates activation of three integrin subfamilies in humans.
Galectin-8 interacts with podoplanin and modulates lymphatic endothelial cell functions.
Fas-mediated apoptosis is regulated by the extracellular matrix protein CCN1 (CYR61) in vitro and in vivo.
Quantitative proteomics identifies a Dab2/integrin module regulating cell migration.
Mouse AMACO, a kidney and skin basement membrane associated molecule that mediates RGD-dependent cell attachment.
Adhesion of human haematopoietic (CD34+) stem cells to human liver compartments is integrin and CD44 dependent and modulated by CXCR3 and CXCR4.
Characterization of integrin engagement during defined human embryonic stem cell culture.
Targeting of integrin beta1 and kinesin 2alpha by microRNA 183.
Defining the membrane proteome of NK cells.
Matrix metalloproteinase-9 promotes chronic lymphocytic leukemia b cell survival through its hemopexin domain.
Characterization of L-plastin interaction with beta integrin and its regulation by micro-calpain.
Integrin expression and integrin-mediated adhesion in vitro of human multipotent stromal cells (MSCs) to endothelial cells from various blood vessels.
Inhibition of β1 integrin and IL-3Rβ common subunit interaction hinders tumour angiogenesis.
Structural diversity in integrin/talin interactions.
The androgen receptor induces integrin α6β1 to promote prostate tumor cell survival via NF-κB and Bcl-xL Independently of PI3K signaling.
The basement membrane of hair follicle stem cells is a muscle cell niche.
Angiopoietin-like 4 protein elevates the prosurvival intracellular O2(-):H2O2 ratio and confers anoikis resistance to tumors.
Analysis of the myosin-II-responsive focal adhesion proteome reveals a role for β-Pix in negative regulation of focal adhesion maturation.
The metastasis-promoting phosphatase PRL-3 shows activity toward phosphoinositides.
SHARPIN is an endogenous inhibitor of β1-integrin activation.
Basic amino-acid side chains regulate transmembrane integrin signalling.
A disintegrin and metalloenzyme (ADAM) 17 activation is regulated by α5β1 integrin in kidney mesangial cells.
Crystal structure of α5β1 integrin ectodomain: atomic details of the fibronectin receptor.
Angiotensin converting enzyme (ACE) and ACE2 bind integrins and ACE2 regulates integrin signalling.
Endoglin mediates fibronectin/α5β1 integrin and TGF-β pathway crosstalk in endothelial cells.
Integrins β1 and β3 exhibit distinct dynamic nanoscale organizations inside focal adhesions.
Integrins αvβ3 and α4β1 act as coreceptors for fractalkine, and the integrin-binding defective mutant of fractalkine is an antagonist of CX3CR1.
Regulation of endodermal differentiation of human embryonic stem cells through integrin-ECM interactions.
Platelet proteome analysis reveals integrin-dependent aggregation defects in patients with myelodysplastic syndromes.
Structural basis for endosomal trafficking of diverse transmembrane cargos by PX-FERM proteins.
In-depth proteomic analyses of exosomes isolated from expressed prostatic secretions in urine.
CBAP functions as a novel component in chemokine-induced ZAP70-mediated T-cell adhesion and migration.
Comparative proteomic analysis of supportive and unsupportive extracellular matrix substrates for human embryonic stem cell maintenance.
Mycobacterium tuberculosis infection of human dendritic cells decreases integrin expression, adhesion and migration to chemokines.
Integrin-β5 and zyxin mediate formation of ventral stress fibers in response to transforming growth factor β.
MicroRNA-223 antagonizes angiogenesis by targeting β1 integrin and preventing growth factor signaling in endothelial cells.
Disease-associated single amino acid mutation in the calf-1 domain of integrin α3 leads to defects in its processing and cell surface expression.
The chemokine fractalkine can activate integrins without CX3CR1 through direct binding to a ligand-binding site distinct from the classical RGD-binding site.
Citrullination of collagen II affects integrin-mediated cell adhesion in a receptor-specific manner.
KSHV attachment and entry are dependent on αVβ3 integrin localized to specific cell surface microdomains and do not correlate with the presence of heparan sulfate.
An RGD motif present in cadherin 17 induces integrin activation and tumor growth.
Proinflammatory secreted phospholipase A2 type IIA (sPLA-IIA) induces integrin activation through direct binding to a newly identified binding site (site 2) in integrins αvβ3, α4β1, and α5β1.
E-cadherin interactome complexity and robustness resolved by quantitative proteomics.
A novel intracellular fibulin-1D variant binds to the cytoplasmic domain of integrin beta 1 subunit.
Direct interactions with the integrin β1 cytoplasmic tail activate the Abl2/Arg kinase.
Association of p75(NTR) and α9β1 integrin modulates NGF-dependent cellular responses.
Odontogenic Ameloblast-associated Protein (ODAM) Mediates Junctional Epithelium Attachment to Teeth via Integrin-ODAM-Rho Guanine Nucleotide Exchange Factor 5 (ARHGEF5)-RhoA Signaling.
Association of the VLA alpha 6 subunit with a novel protein. A possible alternative to the common VLA beta 1 subunit on certain cell lines.
Focal Adhesion Kinase Regulates Fibroblast Migration via Integrin beta-1 and Plays a Central Role in Fibrosis.
The WD40-domain containing protein CORO2B is specifically enriched in glomerular podocytes and regulates the ventral actin cytoskeleton.
CD93 promotes β1 integrin activation and fibronectin fibrillogenesis during tumor angiogenesis.
Histone Interaction Landscapes Visualized by Crosslinking Mass Spectrometry in Intact Cell Nuclei.
Blood-Brain Barrier: From Physiology to Disease and Back.
CD9 Controls Integrin α5β1-Mediated Cell Adhesion by Modulating Its Association With the Metalloproteinase ADAM17.
Regulation of cell migration by α4 and α9 integrins.
Connexin 43 maintains tissue polarity and regulates mitotic spindle orientation in the breast epithelium.
Integrin Binding to the Trimeric Interface of CD40L Plays a Critical Role in CD40/CD40L Signaling.
GRP78 and Integrins Play Different Roles in Host Cell Invasion during Mucormycosis.
Interactome Mapping Provides a Network of Neurodegenerative Disease Proteins and Uncovers Widespread Protein Aggregation in Affected Brains.
The Integrin Binding Peptide, ATN-161, as a Novel Therapy for SARS-CoV-2 Infection.
Dual proteome-scale networks reveal cell-specific remodeling of the human interactome.
Structural insights into integrin α(5)β(1) opening by fibronectin ligand.
Physical and functional interactome atlas of human receptor tyrosine kinases.
PEAK1 Y635 phosphorylation regulates cell migration through association with Tensin3 and integrins.
The integrin ligand SVEP1 regulates GPCR-mediated vasoconstriction via integrins α9β1 and α4β1.
The C-type lectin domain of CD62P (P-selectin) functions as an integrin ligand.
Regulated expression of p150,95 (CD11c/CD18; alpha X/beta 2) and VLA-4 (CD49d/CD29; alpha 4/beta 1) integrins during myeloid cell differentiation.
ICAP-1, a novel beta1 integrin cytoplasmic domain-associated protein, binds to a conserved and functionally important NPXY sequence motif of beta1 integrin.
NAG-2, a novel transmembrane-4 superfamily (TM4SF) protein that complexes with integrins and other TM4SF proteins.
Spatial and temporal expression of the beta1D integrin during mouse development.
Knockout of alpha6 beta1-integrin expression reverses the transformed phenotype of hepatocarcinoma cells.
Isolation, cloning, and sequence analysis of the integrin subunit alpha10, a beta1-associated collagen binding integrin expressed on chondrocytes.
Filamin binds to the cytoplasmic domain of the beta1-integrin. Identification of amino acids responsible for this interaction.
VCAM1 binds Integrin alpha4beta1
Integrin alpha4beta1 binds JAM2:JAM3
Integrin alpha5beta1 binds FN1 dimer
BSG (basigin) binds Integrin alpha3beta1, alpha6beta1
Collagen type II binds integrin alpha10beta1
Collagen type I binds integrin alpha11beta1
Integrins alpha3beta1, alpha6beta4 bind laminin-332, 511, 521, (211, 221)
Integrins alpha4beta1, alpha8beta1, alphaVbeta1, alphaVbeta3, alphaVbeta6 bind Fibronectin matrix
Integrin alpha7beta1 binds Laminin-211, 221, 411, 512, 521
Interaction of integrin alpha8beta1 with Tenascin-C
Interaction of integrin alpha9beta1 with Tenascin-C
Collagen types III, IV, V, VI, VIII, IX, XVI bind integrins alpha1beta1 and alpha2beta1
Fibrillin-1 binds integrins
Latent TGF-beta-1 binds integrins
Latent TGF-beta-3 binds integrins
COMP binds Integrin alpha5beta1, Integrin alphaVbeta3, CD47
VTN binds integrins alphaVbeta1, alphaVbeta3, alpha3beta5, alphaIIBbeta3
Collagen type XIII binds Integrin alpha1beta1
SPP1 (osteopontin) binds integrin alpha5beta1, alpha9beta1
Interaction of integrin alpha9beta1 with VCAM1
THBS1 (Thrombospondin-1) binds Integrin alpha3beta1, alpha4beta1
TNC binds Integrin alphaVbeta3, alphaVbeta6, alpha2beta1, alpha7beta1, alpha8beta1, alpha9beta1, alphaXbeta1
Syndecan-1 binds Integrins alpha2beta1, (alpha6beta4)
Integrin alpha2beta1 binds laminin-332
L1 interaction with Integrins
Integrin alpha6beta1 binds laminin-322, 512, 521, 211, 221, 411
Collagen types VI, IX bind integrin alpha10beta1
Arresten binds integrin alpha1beta1
Tumstatin binds integrin alphaVbeta 3, alpha3beta1
LUM (lumican) binds integrin alpha2beta1
Dentin phosphoprotein binds integrin alphaVbeta1
Collagen type VII binds integrin alpha2beta1
Collagen type IX binds integrin alpha11beta1
Endorepellin binds alpha2beta1 integrin
Endostatin binds integrin alphaVbeta3, alphaVbeta5, alpha3beta1, alpha5beta1
ILK interacts with beta-1 integrin
SRF:MKL1 stimulate ITGB1 expression while SCAI inhibits it
Expression of IL13-upregulated plasma membrane proteins
HCMV Binds to the Host Cell via heparan sulfate proteoglycans (HSPG)
HCMV Binds Host Cell Receptor - Endocytic Pathway
Endocytic Uptake of HCMV Virion
Fusion of HCMV Envelope with Plasma Membrane
p-SHC1 binds integrin alpha5beta1:fibronectin
ITGA4:ITGB1 binds natalizumab
p-S26-ANXA2 binds integrin alpha5:beta1 at the plasma membrane
PP2A dephosphorylates serine-127 of YAP1
Collagen type XXIII binds Integrin alpha2beta1
Collagen type X binds integrin alpha2beta1
Osteopontin binds Integrin alpha4beta1
Integrin alpha6beta1, alpha7beta1, alpha1beta1, alpha2beta1, alphaVbeta1 bind laminin-111
Collagen type II binds integrin alpha2beta1, alpha1beta1, alpha11beta1
Collagen type I binds integrin alpha1beta1, alpha2beta1, alpha10beta1
Collagen type IV binds integrin alpha2beta1, alpha1beta1
Collagen type IV binds integrin alpha10beta1
Ancient origin of the integrin-mediated adhesion and signaling machinery.
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Capsaspora owczarzaki has four integrin beta and four integrin alpha genes; Amastigomonas has one of each.
"we found four integrin β and four integrin α genes in C. owczarzaki"
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Choanoflagellates and fungi lack integrin alpha and beta, presumably by independent loss.
"Integrin α and β and several other components of the integrin adhesion complex are absent from choanoflagellates and fungi and were presumably lost independently in these lineages."
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Non-metazoan integrin beta subunits conserve the cation-binding motifs and the cytoplasmic NPXY motif.
"are well conserved in the different nonmetazoan integrin β, except for C. owczarzaki integrin β4"
Integrin-Mediated Adhesion in the Unicellular Holozoan Capsaspora owczarzaki.
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Capsaspora adheres to substrate through actin-dependent filopodia containing integrin beta2 and vinculin patches; an anti-integrin beta2 antibody inhibits adhesion to fibronectin.
"We show that integrin β2 and its associated protein vinculin localize as distinct patches in the filopodia."