Gene Ontology annotation through association of InterPro records with GO terms
Annotation inferences using phylogenetic trees
Gene Ontology annotation based on UniProtKB/Swiss-Prot Subcellular Location vocabulary mapping, accompanied by conservative changes to GO terms applied by UniProt
Gene Ontology annotation based on curation of intracellular localizations of expressed fusion proteins in living cells
Automatic Gene Ontology annotation based on Rhea mapping
Electronic Gene Ontology annotations created by ARBA machine learning models
Combined Automated Annotation using Multiple IEA Methods
Biochemical and molecular genetic analyses on placental aromatase (P-450AROM) deficiency.
Structural basis for androgen specificity and oestrogen synthesis in human aromatase.
Oxidation of dihydrotestosterone by human cytochromes P450 19A1 and 3A4.
Osteopontin promotes aromatase expression and estradiol production in human adipocytes.
Impact of R264C and R264H polymorphisms in human aromatase function.
Isolation of a full-length cDNA insert encoding human aromatase system cytochrome P-450 and its expression in nonsteroidogenic cells.
Cloning of a complete cDNA encoding human aromatase: immunochemical identification and sequence analysis.
Oocyte-Secreted Factors Synergize With FSH to Promote Aromatase Expression in Primary Human Cumulus Cells.
CYP19A1 hydroxylates ANDST to E1
CYP19A1 hydroxylates TEST to EST17b
Defective CYP19A1 does not convert ANDST to E1
CYP19A1 binds Aromatase inhibitors
UniProtKB P11511 CYP19A1 (CP19A_HUMAN) record
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UniProt describes aromatase as a cytochrome P450 monooxygenase that converts C19 androgens (androstenedione, testosterone) to C18 estrogens (estrone, 17beta-estradiol) via three successive oxidations using O2 and NADPH through cytochrome P450 reductase; it binds heme, localizes to the endoplasmic reticulum/microsome membrane as a multi-pass membrane protein, is widely expressed (brain, placenta, adipose, gonads), and its loss/gain causes aromatase deficiency / aromatase excess syndrome.