Gene Ontology annotation through association of InterPro records with GO terms
Manual transfer of experimentally-verified manual GO annotation data to orthologs by curator judgment of sequence similarity
Annotation inferences using phylogenetic trees
Automatic transfer of experimentally verified manual GO annotation data to orthologs using Ensembl Compara
Electronic Gene Ontology annotations created by ARBA machine learning models
Combined Automated Annotation using Multiple IEA Methods
Requirement of type III TGF-beta receptor for endocardial cell transformation in the heart.
Differential mechanisms of inorganic pyrophosphate production by plasma cell membrane glycoprotein-1 and B10 in chondrocytes.
Betaglycan binds inhibin and can mediate functional antagonism of activin signalling.
Activin receptor-like kinase 2 can mediate atrioventricular cushion transformation.
Specific sequence motif of 8-Cys repeats of TGF-beta binding proteins, LTBPs, creates a hydrophobic interaction surface for binding of small latent TGF-beta.
Type III TGF-beta receptor-independent signalling of TGF-beta2 via TbetaRII-B, an alternatively spliced TGF-beta type II receptor.
Human leiomyoma smooth muscle cells show increased expression of transforming growth factor-beta 3 (TGF beta 3) and altered responses to the antiproliferative effects of TGF beta.
Altered growth responses of pulmonary artery smooth muscle cells from patients with primary pulmonary hypertension to transforming growth factor-beta(1) and bone morphogenetic proteins.
Human activation-induced cytidine deaminase is induced by IL-4 and negatively regulated by CD45: implication of CD45 as a Janus kinase phosphatase in antibody diversification.
Transforming growth factor-beta-mediated chondrogenesis of human mesenchymal progenitor cells involves N-cadherin and mitogen-activated protein kinase and Wnt signaling cross-talk.
Endoglin is a component of the transforming growth factor-beta receptor system in human endothelial cells.
TGF beta signals through a heteromeric protein kinase receptor complex.
Myostatin signals through a transforming growth factor beta-like signaling pathway to block adipogenesis.
Differential regulation of TGF-beta signaling through Smad2, Smad3 and Smad4.
SB-431542 and Gleevec inhibit transforming growth factor-beta-induced proliferation of human osteosarcoma cells.
Impaired IgA class switching in APRIL-deficient mice.
Cooperation between TGF-beta and Wnt pathways during chondrocyte and adipocyte differentiation of human marrow stromal cells.
Up-regulation of acyl-coenzyme A:cholesterol acyltransferase-1 by transforming growth factor-beta1 during differentiation of human monocytes into macrophages.
Vasorin, a transforming growth factor beta-binding protein expressed in vascular smooth muscle cells, modulates the arterial response to injury in vivo.
Hepatitis C viral proteins interact with Smad3 and differentially regulate TGF-beta/Smad3-mediated transcriptional activation.
FLRG, member of the follistatin family, a new player in hematopoiesis.
Interaction and functional interplay between endoglin and ALK-1, two components of the endothelial transforming growth factor-beta receptor complex.
A functional SNP in CILP, encoding cartilage intermediate layer protein, is associated with susceptibility to lumbar disc disease.
Targeted inhibition of p57 and p15 blocks transforming growth factor beta-inhibited proliferation of primary cultured human limbal epithelial cells.
Growth factor regulation of hyaluronan synthesis and degradation in human dermal fibroblasts: importance of hyaluronan for the mitogenic response of PDGF-BB.
Smad7 antagonizes transforming growth factor beta signaling in the nucleus by interfering with functional Smad-DNA complex formation.
Mechanisms for asporin function and regulation in articular cartilage.
Cholesterol suppresses cellular TGF-beta responsiveness: implications in atherogenesis.
Loss of type III transforming growth factor beta receptor expression increases motility and invasiveness associated with epithelial to mesenchymal transition during pancreatic cancer progression.
Opposite regulation of transforming growth factors-beta2 and -beta3 expression in the human endometrium.
TGF-beta1 and TGF-beta2 expression after traumatic human spinal cord injury.
Developing human minor salivary glands: morphological parallel relation between the expression of TGF-beta isoforms and cytoskeletal markers of glandular maturation.
Activation of a TGF-beta-specific multistep gene expression program in mature macrophages requires glucocorticoid-mediated surface expression of TGF-beta receptor II.
Transforming growth factor-beta1, transforming growth factor-beta2, and transforming growth factor-beta3 enhance ovarian cancer metastatic potential by inducing a Smad3-dependent epithelial-to-mesenchymal transition.
SMAD proteins control DROSHA-mediated microRNA maturation.
Differential involvement of TGF-beta1 in mediating the motogenic effects of TSP-1 on endothelial cells, fibroblasts and oral tumour cells.
Smad7 stabilizes beta-catenin binding to E-cadherin complex and promotes cell-cell adhesion.
Transforming growth factor beta engages TACE and ErbB3 to activate phosphatidylinositol-3 kinase/Akt in ErbB2-overexpressing breast cancer and desensitizes cells to trastuzumab.
Latent TGF-beta binding proteins (LTBPs)-1 and -3 coordinate proliferation and osteogenic differentiation of human mesenchymal stem cells.
HMGA2 and Smads co-regulate SNAIL1 expression during induction of epithelial-to-mesenchymal transition.
IL-4-induced selective clearance of oligomeric beta-amyloid peptide(1-42) by rat primary type 2 microglia.
Holding their own: the noncanonical roles of Smad proteins.
Myostatin reduces Akt/TORC1/p70S6K signaling, inhibiting myoblast differentiation and myotube size.
Transforming growth factor beta1 signaling via interaction with cell surface Hyal-2 and recruitment of WWOX/WOX1.
Expression of vascular endothelial growth factor is coordinately regulated by the activin-like kinase receptors 1 and 5 in endothelial cells.
GARP (LRRC32) is essential for the surface expression of latent TGF-beta on platelets and activated FOXP3+ regulatory T cells.
Mesenchymal stem cells produce Wnt isoforms and TGF-beta1 that mediate proliferation and procollagen expression by lung fibroblasts.
Endoglin phosphorylation by ALK2 contributes to the regulation of prostate cancer cell migration.
Suppression of type I collagen production by microRNA-29b in cultured human stellate cells.
High glucose down-regulates miR-29a to increase collagen IV production in HK-2 cells.
A role of the latent TGF-beta 1-binding protein in the assembly and secretion of TGF-beta 1.
Agrin binds BMP2, BMP4 and TGFbeta1.
Critical role of endoglin in tumor cell plasticity of Ewing sarcoma and melanoma.
DIP2 disco-interacting protein 2 homolog A (Drosophila) is a candidate receptor for follistatin-related protein/follistatin-like 1--analysis of their binding with TGF-β superfamily proteins.
TGF-β2 suppresses macrophage cytokine production and mucosal inflammatory responses in the developing intestine.
WFIKKN1 and WFIKKN2 bind growth factors TGFβ1, BMP2 and BMP4 but do not inhibit their signalling activity.
Tyrosine phosphorylation of VE-cadherin and claudin-5 is associated with TGF-β1-induced permeability of centrally derived vascular endothelium.
Transforming growth factor-beta bound to soluble derivatives of the beta amyloid precursor protein of Alzheimer's disease.
The role of bone morphogenetic protein-5 (BMP-5) in human nephrosclerosis.
SCUBE3 is an endogenous TGF-β receptor ligand and regulates the epithelial-mesenchymal transition in lung cancer.
Multiple targets of miR-302 and miR-372 promote reprogramming of human fibroblasts to induced pluripotent stem cells.
Latent TGF-β structure and activation.
Smad6-specific recruitment of Smurf E3 ligases mediates TGF-β1-induced degradation of MyD88 in TLR4 signalling.
Poly(ADP-ribose) polymerase 1 is indispensable for transforming growth factor-β Induced Smad3 activation in vascular smooth muscle cell.
Inhibition of microRNA-29b reduces murine abdominal aortic aneurysm development.
Proteomic analysis of microvesicles from plasma of healthy donors reveals high individual variability.
MicroRNA-181a regulates local immune balance by inhibiting proliferation and immunosuppressive properties of mesenchymal stem cells.
SILAC-based proteomics of human primary endothelial cell morphogenesis unveils tumor angiogenic markers.
HCV NS3 protease enhances liver fibrosis via binding to and activating TGF-β type I receptor.
MicroRNA-326 regulates profibrotic functions of transforming growth factor-β in pulmonary fibrosis.
TGF-β-inducible microRNA-183 silences tumor-associated natural killer cells.
Inhibitory effect of hsa-miR-590-5p on cardiosphere-derived stem cells differentiation through downregulation of TGFB signaling.
Inhibition of TGF-β/SMAD3/NF-κB signaling by microRNA-491 is involved in arsenic trioxide-induced anti-angiogenesis in hepatocellular carcinoma cells.
Using an in situ proximity ligation assay to systematically profile endogenous protein-protein interactions in a pathway network.
Sustained induction of collagen synthesis by TGF-β requires regulated intramembrane proteolysis of CREB3L1.
MicroRNA-34a regulates cardiac fibrosis after myocardial infarction by targeting Smad4.
A proteome-scale map of the human interactome network.
Induction and activation of latent transforming growth factor-β1 are carried out by two distinct domains of pregnancy-specific glycoprotein 1 (PSG1).
Reduction of miR-29c enhances pancreatic cancer cell migration and stem cell-like phenotype.
Syntenin regulates TGF-β1-induced Smad activation and the epithelial-to-mesenchymal transition by inhibiting caveolin-mediated TGF-β type I receptor internalization.
miR-208-3p promotes hepatocellular carcinoma cell proliferation and invasion through regulating ARID2 expression.
MicroRNA-143 Activation Regulates Smooth Muscle and Endothelial Cell Crosstalk in Pulmonary Arterial Hypertension.
miRNA-34a reduces neointima formation through inhibiting smooth muscle cell proliferation and migration.
Rotavirus-induced miR-142-5p elicits proviral milieu by targeting non-canonical transforming growth factor beta signalling and apoptosis in cells.
Valve Endothelial Cell-Derived Tgfβ1 Signaling Promotes Nuclear Localization of Sox9 in Interstitial Cells Associated With Attenuated Calcification.
The microRNA-29 family in cartilage homeostasis and osteoarthritis.
MicroRNA-323-3p inhibits cell invasion and metastasis in pancreatic ductal adenocarcinoma via direct suppression of SMAD2 and SMAD3.
Genotype-Specific Interaction of Latent TGFβ Binding Protein 4 with TGFβ.
Autophagy inhibition of hsa-miR-19a-3p/19b-3p by targeting TGF-β R II during TGF-β1-induced fibrogenesis in human cardiac fibroblasts.
Regulation and function of miR-214 in pulmonary arterial hypertension.
Regulation of the Bioavailability of TGF-β and TGF-β-Related Proteins.
Functional consequence of fibulin-4 missense mutations associated with vascular and skeletal abnormalities and cutis laxa.
Vascular mimicry formation is promoted by paracrine TGF-β and SDF1 of cancer-associated fibroblasts and inhibited by miR-101 in hepatocellular carcinoma.
miR-27b inhibits fibroblast activation via targeting TGFβ signaling pathway.
miR-202 Diminishes TGFβ Receptors and Attenuates TGFβ1-Induced EMT in Pancreatic Cancer.
PPARγ Links BMP2 and TGFβ1 Pathways in Vascular Smooth Muscle Cells, Regulating Cell Proliferation and Glucose Metabolism.
Architecture of the human interactome defines protein communities and disease networks.
Cartilage intermediate layer protein 1 (CILP1): A novel mediator of cardiac extracellular matrix remodelling.
Human TGF-β1 deficiency causes severe inflammatory bowel disease and encephalopathy.
Transmembrane protease, serine 4 (TMPRSS4) is upregulated in IPF lungs and increases the fibrotic response in bleomycin-induced lung injury.
A Milieu Molecule for TGF-β Required for Microglia Function in the Nervous System.
Structural basis of latent TGF-β1 presentation and activation by GARP on human regulatory T cells.
LRP1 Deficiency in Vascular SMC Leads to Pulmonary Arterial Hypertension That Is Reversed by PPARγ Activation.
HIF1A/miR-20a-5p/TGFβ1 axis modulates adipose-derived stem cells in a paracrine manner to affect the angiogenesis of human dermal microvascular endothelial cells.
Long noncoding RNA DNM3OS promotes prostate stromal cells transformation via the miR-29a/29b/COL3A1 and miR-361/TGFβ1 axes.
miR-4286/TGF-β1/Smad3-Negative Feedback Loop Ameliorated Vascular Endothelial Cell Damage by Attenuating Apoptosis and Inflammatory Response.
A reference map of the human binary protein interactome.
The deubiquitinase USP44 promotes Treg function during inflammation by preventing FOXP3 degradation.
Dual proteome-scale networks reveal cell-specific remodeling of the human interactome.
Tenascin-X Mediates Flow-Induced Suppression of EndMT and Atherosclerosis.
Multimodal cell maps as a foundation for structural and functional genomics.
The soluble exoplasmic domain of the type II transforming growth factor (TGF)-beta receptor. A heterogeneously glycosylated protein with high affinity and selectivity for TGF-beta ligands.
Cloning and developmental expression of the chick type II and type III TGF beta receptors.
Identification and expression of two forms of the human transforming growth factor-beta-binding protein endoglin with distinct cytoplasmic regions.
Association of the small latent transforming growth factor-beta with an eight cysteine repeat of its binding protein LTBP-1.
Dual role of the Smad4/DPC4 tumor suppressor in TGFbeta-inducible transcriptional complexes.
Thrombin stimulates fibroblast procollagen production via proteolytic activation of protease-activated receptor 1.
Inhibition of myogenesis by transforming growth factor beta is density-dependent and related to the translocation of transcription factor MEF2 to the cytoplasm.
Bone morphogenetic proteins and growth and differentiation factors in the human cornea.
NA activation of TGF-beta
An anchoring protein, ZFYVE9 (SARA), recruits SMAD2/3
TGFBR2 phosphorylates TGFBR1
Latent TGF-beta-1 is cleaved by FURIN
Phosphorylated SMAD2/3 dissociates from TGFBR
Dimeric TGF-beta-1 binds to the receptor
Activated type I receptor phosphorylates SMAD2/3 directly
BAMBI interferes with the interaction of type I receptor with type II receptor
I-SMAD competes with SMAD2/3 for type I receptor (TGFBR1)
Secretion and activation of the latent large complex of TGF-beta-1
STRAP stabilizes interaction of activated TGF-beta receptor complex with SMAD7
Disassembly of tight junctions
SMURF1 binds phosphorylated PARD6A
SMURF1 ubiquitinates RHOA
Degradation of TGF-beta receptor complex
Latent TGF-beta-1 binds integrins
LTBP1, LTBP3 bind TGF-Beta
Syndecans 2, (4) bind TGFB1
Activated TGFBR1 cannot phosphorylate SMAD2 and SMAD3 Phosphorylation Motif Mutants
Dimeric TGFB1 does not bind TGFBR2 MSI frameshift mutants
TGFBR2 KD mutants do not phosphorylate TGFBR1
TGFBR2 does not recruit TGFBR1 LBD Mutants
An anchoring protein ZFYVE9 (SARA) does not recruit SMAD2/3 to TGFB1:TGFBR2:p-TGFBR1 KD Mutants
Exocytosis of platelet alpha granule contents
Expression of STAT3-upregulated extracellular proteins
PSGs bind proteoglycans and TGF-beta1
Endocytosis of TGFBR3:ARRB complex
TGFBR3 phosphorylation by TGFBR2 complex
TGFBR3(1-783) binds to TGFB1,TGFB2
TGFBR3 binding to ARRB1/2
TGFBR3 complex binds to TGFBR2
Strap binds phosphorylated TGF-beta receptor complex
TGFBR2 is recruited to tight junctions-associated, Pard6a-bound, TGFBR1 after TGF-beta stimulation
TGFBR2 phosphorylates Pard6a
PP1CC dephosphorylates TGFBR1
Smad7 recruits GADD34:PP1CC to phosphorylated TGF-beta receptor complex
Smad7:SMURF1 binds phosphorylated TGFBR1
Smad7:SMURF2 binds phosphorylated TGFBR1
SMURF2 ubiquitinates Smad7 and phosphorylated TGFBR1
SMURF1 ubiquitinates Smad7 and phosphorylated TGFBR1
NEDD4L ubiquitinates Smad7 and TGFBR1
Smad7 recruits NEDD4L to activated TGF-beta receptor complex
Uchl5 is recruited to TGF-beta receptor complex through Smad7
Uchl5 deubiquitinates TGFBR1
UniProt record P01137 (TGFB1_HUMAN)