Kpc1 (CG6752; Q9VFC4) notes

Identity

• RNF123/KPC1 homologue: N-terminal SPRY (B30.2) domain and C-terminal RING finger (UniProt InterPro IPR045129 RNF123/RKP/RSPRY1; IPR001841 Znf_RING); UniProt assigns EC 2.3.2.27 by ARBA rule.

Literature journal

• Fly KPC complex discovered in a male-sterility screen PMID:33378371.
• Complex and mutual stabilization PMID:33378371.
• Male sterility through sperm storage failure PMID:33378371.
• No direct binding to Amo PMID:33378371.
• RING survey PMID:21912646 supports RING-E3 assignment (ISM zinc binding).
• Falcon deep research (Kpc1-deep-research-falcon.md): fly E3 catalysis not directly assayed; dKPC1 required for dKPC2 monoubiquitination; Amo is a localization client, not shown to be a substrate.

Curation thoughts

• MF: RING E3 ubiquitin ligase (phylogenetic/ISS + conserved RING) - accepted; no fly biochemical assay.
• Sperm storage is a necessity phenotype; kept non-core.
• Protein catabolic process (IBA) reflects mammalian KPC p27 degradation; fly substrate unknown, kept non-core.