Gene Ontology annotation through association of InterPro records with GO terms
Annotation inferences using phylogenetic trees
Gene Ontology annotation based on UniProtKB/Swiss-Prot keyword mapping
Gene Ontology annotation based on UniProtKB/Swiss-Prot Subcellular Location vocabulary mapping
Combined Automated Annotation using Multiple IEA Methods
Combinatorial expression of TRPV channel proteins defines their sensory functions and subcellular localization in C. elegans neurons.
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OCR-2 and OSM-9 co-localize in sensory cilia and promote each other's ciliary localization
"In neurons that express both OSM-9 and OCR-2, tagged OCR-2 and OSM-9 proteins reside in sensory cilia and promote each other's localization to cilia"
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Both OSM-9 and OCR-2 are essential for olfaction, osmosensation, mechanosensation, and chemosensation
"Both OSM-9 and OCR-2 are essential for several forms of sensory transduction, including olfaction, osmosensation, mechanosensation, and chemosensation"
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In neurons expressing only OSM-9, protein resides in cell body for adaptation rather than transduction
"In neurons that express only OSM-9, tagged OSM-9 protein resides in the cell body and acts in sensory adaptation rather than sensory transduction"
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Heteromeric TRPV assembly is required for sensory transduction function
"distinct sensory functions arise from different combinations of OSM-9 and related OCR TRPV proteins"
Polymodal sensory function of the Caenorhabditis elegans OCR-2 channel arises from distinct intrinsic determinants within the protein and is selectively conserved in mammalian TRPV proteins.
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OCR-2 regulates serotonin (5-HT) biosynthesis in ADF chemosensory neurons
"OCR-2 (OSM-9 and capsaicin receptor-related) is a TRPV (vanilloid subfamily of transient receptor potential channel) protein that regulates serotonin (5-HT) biosynthesis in chemosensory neurons"
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OCR-2 mediates olfactory and osmotic sensation through different molecular determinants
"mediates olfactory and osmotic sensation. Here, we identify the molecular basis for the polymodal function of OCR-2"
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N-terminal region governs 5-HT production and osmotic sensing
"OCR-2 function in 5-HT production and osmotic sensing is governed by its N-terminal region upstream of the ankyrin repeats domain"
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Diacetyl sensitivity mediated by independent mechanisms
"the diacetyl sensitivity is mediated by independent mechanisms"
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G36E substitution (ocr-2(yz5)) eliminates osmosensation in ASH but not diacetyl response in AWA
"The G36E substitution causes dramatic downregulation of 5-HT synthesis in the ADF neurons, eliminates osmosensation mediated by the ASH neurons, but does not affect the response to the odorant diacetyl mediated by the AWA neurons"
OSM-9 and OCR-2 TRPV channels are accessorial warm receptors in Caenorhabditis elegans temperature acclimatisation.
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OSM-9/OCR-2 heteromeric channel acts as accessorial warmth-sensing receptor in ADL neurons
"OSM-9/OCR-2 regulates temperature acclimatisation and acts as an accessorial warmth-sensing receptor in ADL neurons"
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TRPV mutants show abnormal temperature acclimatization with elevated cold tolerance
"Caenorhabditis elegans TRPV channel mutants showed abnormal temperature acclimatisation"
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Neither subunit alone produces warming-evoked currents; heteromerization required
"OSM-9 and OCR-2 cooperatively responded to warming; however, neither TRPV subunit alone was responsive to warming"
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Warming-evoked inward currents with outward-rectifying I-V in Xenopus oocytes
"Thermal stimuli evoked inward currents in Xenopus oocytes co-expressing OSM-9 and OCR-2"
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Ectopic expression in ASER neurons confers temperature responsiveness
"Ectopic expression of OSM-9 and OCR-2 in non-warming-responsive gustatory neurons in C. elegans and Xenopus oocytes revealed that OSM-9 and OCR-2 cooperatively responded to warming"
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ADL responds to warming over approximately 13-27 degrees C range
"warming stimuli in the osm-9 ocr-2; ocr-1 triple mutant revealed decreased thermal responses compared with wild-type"