Gene Ontology annotation through association of InterPro records with GO terms

Manual transfer of experimentally-verified manual GO annotation data to orthologs by curator judgment of sequence similarity

Annotation inferences using phylogenetic trees

Gene Ontology annotation based on UniProtKB/Swiss-Prot Subcellular Location vocabulary mapping, accompanied by conservative changes to GO terms applied by UniProt

Automated transfer of experimentally-verified manual GO annotation data to mouse-rat orthologs

Automatic transfer of experimentally verified manual GO annotation data to orthologs using Ensembl Compara

Electronic Gene Ontology annotations created by ARBA machine learning models

Automated transfer of experimentally-verified manual GO annotation data to mouse-human orthologs

Combined Automated Annotation using Multiple IEA Methods

Identification of profilin and src homology 3 domains as binding partners for Drosophila enabled.

Src and Pyk2 mediate G-protein-coupled receptor activation of epidermal growth factor receptor (EGFR) but are not required for coupling to the mitogen-activated protein (MAP) kinase signaling cascade.

Delphilin: a novel PDZ and formin homology domain-containing protein that synaptically colocalizes and interacts with glutamate receptor delta 2 subunit.

Modulation of the F-actin cytoskeleton by c-Abl tyrosine kinase in cell spreading and neurite extension.

Src-induced phosphorylation of caveolin-2 on tyrosine 19. Phospho-caveolin-2 (Tyr(P)19) is localized near focal adhesions, remains associated with lipid rafts/caveolae, but no longer forms a high molecular mass hetero-oligomer with caveolin-1.

Reelin activates SRC family tyrosine kinases in neurons.

Regulation of cytochrome c oxidase activity by c-Src in osteoclasts.

Gab1 is an integrator of cell death versus cell survival signals in oxidative stress.

EphB1 recruits c-Src and p52Shc to activate MAPK/ERK and promote chemotaxis.

A caveolin-3 mutant that causes limb girdle muscular dystrophy type 1C disrupts Src localization and activity and induces apoptosis in skeletal myotubes.

Phosphorylation-dependent paxillin-ERK association mediates hepatocyte growth factor-stimulated epithelial morphogenesis.

Regulation of connexin43 protein complexes by intracellular acidification.

Src kinase activity is essential for osteoclast function.

Alterations in cell-adhesive and migratory properties of proximal tubule and collecting duct cells from bcl-2 -/- mice.

A role for mitogen-activated protein kinase(Erk1/2) activation and non-selective pore formation in P2X7 receptor-mediated thymocyte death.

c-Src-null mice exhibit defects in normal mammary gland development and ERalpha signaling.

Absence of Fyn and Src causes a reeler-like phenotype.

A proteomics strategy for the enrichment of receptor-associated complexes.

EphB receptors regulate dendritic spine morphogenesis through the recruitment/phosphorylation of focal adhesion kinase and RhoA activation.

Role of Src in C3 transient receptor potential channel function and evidence for a heterogeneous makeup of receptor- and store-operated Ca2+ entry channels.

PSD-95 is a negative regulator of the tyrosine kinase Src in the NMDA receptor complex.

Ccpg1, a novel scaffold protein that regulates the activity of the Rho guanine nucleotide exchange factor Dbs.

CD44 is the signaling component of the macrophage migration inhibitory factor-CD74 receptor complex.

The transcriptional repressor Glis2 is a novel binding partner for p120 catenin.

The membrane targeting and spatial activation of Src, Yes and Fyn is influenced by palmitoylation and distinct RhoB/RhoD endosome requirements.

Src-dependent phosphorylation of ASAP1 regulates podosomes.

Laminin-induced activation of Rac1 and JNKp46 is initiated by Src family kinases and mimics the effects of skeletal muscle contraction.

Dramatic inhibition of osteoclast sealing ring formation and bone resorption in vitro by a WASP-peptide containing pTyr294 amino acid.

Mobility of TOAC spin-labelled peptides binding to the Src SH3 domain studied by paramagnetic NMR.

Palmitoylation-dependent endosomal localization of AATYK1A and its interaction with Src.

Deficiency of a beta-arrestin-2 signal complex contributes to insulin resistance.

Impaired gastric acidification negatively affects calcium homeostasis and bone mass.

Dishevelled-2 docks and activates Src in a Wnt-dependent manner.

CXCR4-mediated bone marrow progenitor cell maintenance and mobilization are modulated by c-kit activity.

Roles of the SH2 and SH3 domains in the regulation of neuronal Src kinase functions.

Linker length dependent binding of a focal adhesion kinase derived peptide to the Src SH3-SH2 domains.

Nε-lysine acetylation determines dissociation from GAP junctions and lateralization of connexin 43 in normal and dystrophic heart.

The guanine nucleotide exchange factor Arhgef5 plays crucial roles in Src-induced podosome formation.

Redox-induced Src kinase and caveolin-1 signaling in TGF-β1-initiated SMAD2/3 activation and PAI-1 expression.

NKX2-1/TITF1/TTF-1-Induced ROR1 is required to sustain EGFR survival signaling in lung adenocarcinoma.

Interchangeability of Themis1 and Themis2 in thymocyte development reveals two related proteins with conserved molecular function.

A Src family kinase-Shp2 axis controls RUNX1 activity in megakaryocyte and T-lymphocyte differentiation.

Protein tyrosine phosphatase α phosphotyrosyl-789 binds BCAR3 to position Cas for activation at integrin-mediated focal adhesions.

Abl family kinases regulate FcγR-mediated phagocytosis in murine macrophages.

Osteopetrosis, osteopetrorickets and hypophosphatemic rickets differentially affect dentin and enamel mineralization.

Targeted disruption of leucine-rich repeat kinase 1 but not leucine-rich repeat kinase 2 in mice causes severe osteopetrosis.

A signaling cascade mediated by ceramide, src and PDGFRβ coordinates the activation of the redox-sensitive neutral sphingomyelinase-2 and sphingosine kinase-1.

Phosphorylation of moesin by Jun N-terminal kinase is important for podosome rosette formation in Src-transformed fibroblasts.

A reactive oxygen species-mediated, self-perpetuating loop persistently activates platelet-derived growth factor receptor α.

Mechanical loading in osteocytes induces formation of a Src/Pyk2/MBD2 complex that suppresses anabolic gene expression.

Caveolin-1 modulates cardiac gap junction homeostasis and arrhythmogenecity by regulating cSrc tyrosine kinase.

Actin filament-associated protein 1 is required for cSrc activity and secretory activation in the lactating mammary gland.

Genetic disruption of the sh3pxd2a gene reveals an essential role in mouse development and the existence of a novel isoform of tks5.

A gp130-Src-YAP module links inflammation to epithelial regeneration.

Tensin 3 is a new partner of Dock5 that controls osteoclast podosome organization and activity.

Focal Adhesion Kinase-mediated Phosphorylation of Beclin1 Protein Suppresses Cardiomyocyte Autophagy and Initiates Hypertrophic Growth.

c-Src phosphorylation and activation of hexokinase promotes tumorigenesis and metastasis.

Nociceptor-derived Reg3γ prevents endotoxic death by targeting kynurenine pathway in microglia.

Phosphorylation of receptor protein-tyrosine phosphatase alpha on Tyr789, a binding site for the SH3-SH2-SH3 adaptor protein GRB-2 in vivo.

Identification of a ten-amino acid proline-rich SH3 binding site.

Mena, a relative of VASP and Drosophila Enabled, is implicated in the control of microfilament dynamics.

Bombesin, bradykinin, vasopressin, and phorbol esters rapidly and transiently activate Src family tyrosine kinases in Swiss 3T3 cells. Dissociation from tyrosine phosphorylation of p125 focal adhesion kinase.

Interaction of Src kinases with c-Kit

SFKs phosphorylate Git1

Phosphorylation of Unc5C

Phosphorylation of FAK by Src kinases

Fak/Src phosphorylate p130Cas

Runx1 binds Src

Src phosphorylates Runx1

G alpha (i):GTP binds Src

Src phosphorylates Robo3.1 in response to Ntn1

Pik3r11:Pik3ca,b,d (Pi3k), Plcg2 (PLCgamma2), Grb2:Sos1, Shc1 (Shc), Ptpn11 (Shp2), Grb2:Gab2, Grb2:Gab3, Grap2 (MONA), Cbl:Grb2, Inpp5d (SHIP1), Inppl1 (SHIP2) bind p-8Y-Csf1r and are activated

Csf1r trans-autophosphorylates on multiple tyrosine residues

Csf1r-associated Plcg2 hydrolyzes phosphatidylcholine yielding choline phosphate and 1,2-diacylglycerol

Csf1r-associated PI3K phosphorylates phosphatidylinositol 4,5-bisphosphate

Csf1r-associated Sos1 mediates exchange of GTP for GDP bound to Ras

Src family kinases phosphorylate Cbl in Csf1 dimer:p-Y559-Csf1r dimer:Cbl

p-Y-Cbl autoubiquitinates and multiubiquitinates p-Y-559-Csf12

Csf1 dimer:p-Y559-Csf1r dimer binds Grb2:Sos1

Csf1 dimer:p-Y-559-Csf1r dimer:SFK:Grb2:Sos1 dissociates yielding Csf1 dimer:p-Y-559-Csf1r dimer:SFK and Grb2:Sos1

Csf1 dimer:p-Y559-Csf1r dimer:Fyn,Hck,Src,Yes1 binds Cbl

Csf1 dimer:p-Y559-Csf1r dimer binds Src family kinases Fyn,Hck,Src,Yes1

Active ALK phosphorylates Src

Active ALK binds Src

Src phosphorylates RHOU

BioReason deep research report on Src

Falcon deep research summary for mouse Src

AIGR curator notes for Src