GO_REF:0000104

Electronic Gene Ontology annotations created by transferring manual GO annotations between related proteins based on shared sequence features

GO_REF:0000120

Combined Automated Annotation using Multiple IEA Methods

file:PSEPK/uvrC/uvrC-uniprot.txt

UniProtKB entry for uvrC (Q88FJ7)

The reviewed family record assigns UvrC dual-incision activity and interaction with UvrB.

"UvrC both incises the 5' and 3' sides"

UniProtKB:P0A8G0

Reviewed Escherichia coli UvrC exemplar

The reviewed canonical bacterial UvrC sequence grounds the ISS transfer of DNA endonuclease activity.

PMID:36869664

Structural and functional insights into the activation of the dual incision activity of UvrC, a key player in bacterial NER

Full-length UvrC is the dual-incision endonuclease of bacterial NER; its GIY-YIG (N-terminal) and RNase H-like (C-terminal) nuclease domains perform the 3' and 5' incisions respectively, and UvrC must transition from a closed inactive to an open active state to execute dual incision.

PMID:33477956

A Peek Inside the Machines of Bacterial Nucleotide Excision Repair

Review of bacterial NER describing UvrC recruitment to the UvrB-DNA pre-incision complex and dual incision at defined positions 3' and 5' of the lesion, releasing a short damaged oligonucleotide.