Gene Ontology annotation through association of InterPro records with GO terms
Gene Ontology annotation based on UniProtKB/Swiss-Prot Subcellular Location vocabulary mapping, accompanied by conservative changes to GO terms applied by UniProt
TreeGrafter-generated GO annotations
Sequence variants in SLC16A11 are a common risk factor for type 2 diabetes in Mexico.
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Tagged human SLC16A11 localizes to the endoplasmic reticulum in HeLa cells, and the gene is expressed in liver, salivary gland and thyroid.
"we observed SLC16A11 expression in liver, salivary gland, and thyroid"
Type 2 Diabetes Variants Disrupt Function of SLC16A11 through Two Distinct Mechanisms.
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Human SLC16A11 is a proton-coupled monocarboxylate transporter that moves pyruvate across the plasma membrane.
"These results support a H+-coupled mechanism underlying SLC16A11 transport"
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BSG is required for plasma membrane localization of SLC16A11, and T2D-risk coding variants disrupt the BSG interaction.
"We found that BSG knockout significantly reduces localization of SLC16A11REF to the plasma membrane"
Dysfunction of exhausted T cells is enforced by MCT11-mediated lactate metabolism.
Gain-of-Function Mutations of SLC16A11 Contribute to the Pathogenesis of Type 2 Diabetes.
Gain-of-Function Claims for Type-2-Diabetes-Associated Coding Variants in SLC16A11 Are Not Supported by the Experimental Data.
Type 2 Diabetes Variants in the SLC16A11 Coding Region Are Not Loss-of-Function Mutations.
Adeno-Associated Virus-Mediated Knockdown of SLC16A11 Improves Glucose Tolerance and Hepatic Insulin Signaling in High Fat Diet-Fed Mice.
UniProt record for donkey SLC16A11 (A0A9L0JV53)
UniProt Swiss-Prot record for human SLC16A11 (Q8NCK7)
SLC16A11: donkey-human sequence comparison
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The donkey gene model lacks the region corresponding to human transmembrane helices 1-3.
"The human N-terminal region containing predicted transmembrane helices 1-3 (human 12-32, 54-74, 82-102) therefore has no homologous counterpart in the donkey model"
SLC16A11 (donkey): comparison of all donkey gene models with human MCT11
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Five donkey UniProt entries are transcript models of one Ensembl gene; only A0A8C4PS96 contains the full human MCT11 sequence, and A0A9L0JV53 shares its C-terminal 332 residues exactly with it.
"A0A8C4PS96 (520 aa) is the only donkey model that contains the whole human MCT11 sequence"