Manual transfer of experimentally-verified manual GO annotation data to orthologs by curator judgment of sequence similarity
Annotation inferences using phylogenetic trees
Gene Ontology annotation based on UniProtKB/Swiss-Prot Subcellular Location vocabulary mapping, accompanied by conservative changes to GO terms applied by UniProt
Gene Ontology annotation based on curation of immunofluorescence data
Automatic transfer of experimentally verified manual GO annotation data to orthologs using Ensembl Compara
Electronic Gene Ontology annotations created by ARBA machine learning models
Combined Automated Annotation using Multiple IEA Methods
A GSK3-binding peptide from FRAT1 selectively inhibits the GSK3-catalysed phosphorylation of axin and beta-catenin.
Characterization of the mammalian initiation factor eIF2B complex as a GDP dissociation stimulator protein.
Exp5 exports eEF1A via tRNA from nuclei and synergizes with other transport pathways to confine translation to the cytoplasm.
A severe variant of childhood ataxia with central hypomyelination/vanishing white matter leukoencephalopathy related to EIF21B5 mutation.
eIF2B-related disorders: antenatal onset and involvement of multiple organs.
Decreased guanine nucleotide exchange factor activity in eIF2B-mutated patients.
Mutations linked to leukoencephalopathy with vanishing white matter impair the function of the eukaryotic initiation factor 2B complex in diverse ways.
The life and death of oligodendrocytes in vanishing white matter disease.
Screening for known mutations in EIF2B genes in a large panel of patients with premature ovarian failure.
EIF2B5 mutations compromise GFAP+ astrocyte generation in vanishing white matter leukodystrophy.
Heightened stress response in primary fibroblasts expressing mutant eIF2B genes from CACH/VWM leukodystrophy patients.
An efficient mammalian cell-free translation system supplemented with translation factors.
Stress responses. Mutations in a translation initiation factor identify the target of a memory-enhancing compound.
Expression, purification, and crystallization of Schizosaccharomyces pombe eIF2B.
Structure of the nucleotide exchange factor eIF2B reveals mechanism of memory-enhancing molecule.
A reference map of the human binary protein interactome.
Interactome Mapping Provides a Network of Neurodegenerative Disease Proteins and Uncovers Widespread Protein Aggregation in Affected Brains.
Dual proteome-scale networks reveal cell-specific remodeling of the human interactome.
T-cell activation leads to rapid stimulation of translation initiation factor eIF2B and inactivation of glycogen synthase kinase-3.
Cloning and characterization of cDNAs encoding the epsilon-subunit of eukaryotic initiation factor-2B from rabbit and human.
Formation of eIF2:GDP:eIF2B intermediate
Eukaryotic initiation factor 2B: identification of multiple phosphorylation sites in the epsilon-subunit and their functions in vivo.
Role of translation initiation factor 2B in control of cell survival by the phosphatidylinositol 3-kinase/Akt/glycogen synthase kinase 3beta signaling pathway.
Mammalian stress granules represent sites of accumulation of stalled translation initiation complexes.
Ovarian failure related to eukaryotic initiation factor 2B mutations.
Developmental changes of eukaryotic initiation factor 2B subunits in rat hippocampus.
Ectopic expression of eIF2Bepsilon in rat skeletal muscle rescues the sepsis-induced reduction in guanine nucleotide exchange activity and protein synthesis.
Structural basis for eIF2B inhibition in integrated stress response.
Use of monoclonal antibodies to study the structure and function of eukaryotic protein synthesis initiation factor eIF-2B.
Glycogen synthase kinase-3 is rapidly inactivated in response to insulin and phosphorylates eukaryotic initiation factor eIF-2B.
Regulation of eukaryotic initiation factor-2B activity in muscle of diabetic rats.
Glucose stimulates the activity of the guanine nucleotide-exchange factor eIF-2B in isolated rat islets of Langerhans.
Subunit assembly and guanine nucleotide exchange activity of eukaryotic initiation factor-2B expressed in Sf9 cells.
Inactivation of eIF2B and phosphorylation of PHAS-I in heat-shocked rat hepatoma cells.
EIF2B5 literal database evidence replay
EIF2B5 source evidence and access guide
Subcellular - EIF2B5 - The Human Protein Atlas
UniProtKB Q13144: EIF2B5 (human), curated record