gcy-23 notes

Session 2026-10-08 (claude-code)

Deep research: just deep-research-falcon worm gcy-23 --fallback perplexity-lite failed
(falcon killed at the 600 s timeout; perplexity provider not available in this environment).
No deep-research file was created. Review based on cached publications in publications/,
the UniProt record, and GOA.

Annotation actions: {'MARK_AS_OVER_ANNOTATED': 1, 'ACCEPT': 21, 'REMOVE': 1, 'KEEP_AS_NON_CORE': 7}

Key evidence:
- AFD-specific; modulatory, redundant PMID:16415369
- Single mutant alters IT range but not AFD response threshold PMID:21315599. The IMP detection-of-temperature row was accepted with a caveat (redundant contribution).
- Protein kinase activity IEA REMOVED (pseudokinase); peptide receptor IBA over-annotated.