ampG gene of Pseudomonas aeruginosa and its role in β-lactamase expression.
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In enterobacteria AmpG transports GlcNAc-anhMurNAc and its peptides, the signal for ampC induction.
"transports 1,6-GlcNAc-anhydro-MurNAc and the 1,6-GlcNAc-anhydro-MurNAc peptide"
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ampG inactivation drastically reduces intrinsic beta-lactam resistance.
"inactivation of ampG drastically repressed the intrinsic β-lactam resistance"
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Cloned ampG complements P. aeruginosa and E. coli ampG mutants.
"The cloned ampG gene is able to complement both the P. aeruginosa and the E. coli ampG mutants"
Pseudomonas aeruginosa β-lactamase induction requires two permeases, AmpG and AmpP.
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PhoA/LacZ fusions place AmpG in the inner membrane with 14 TM helices.
"suggesting that AmpG has only 14 TM helices (Figures 4C and 4D)."
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Benzylpenicillin induction of the ampC promoter is lost in ampG and ampP mutants.
"Benzyl-penicillin dependent induction of PampC-lacZ was lost in PAOampG or PAOampP (Figure 6)."
Gene Ontology annotation through association of InterPro records with GO terms
Annotation inferences using phylogenetic trees
Gene Ontology annotation based on UniProtKB/Swiss-Prot Subcellular Location vocabulary mapping, accompanied by conservative changes to GO terms applied by UniProt.