Gene Ontology annotation through association of InterPro records with GO terms
Manual transfer of experimentally-verified manual GO annotation data to orthologs by curator judgment of sequence similarity
Annotation inferences using phylogenetic trees
Gene Ontology annotation based on UniProtKB/Swiss-Prot keyword mapping
Gene Ontology annotation based on UniProtKB/Swiss-Prot Subcellular Location vocabulary mapping, accompanied by conservative changes to GO terms applied by UniProt
Gene Ontology annotation based on curation of immunofluorescence data
Electronic Gene Ontology annotations created by ARBA machine learning models
Combined Automated Annotation using Multiple IEA Methods
Three proteins define a class of human histone deacetylases related to yeast Hda1p.
Regulation of histone deacetylase 4 and 5 and transcriptional activity by 14-3-3-dependent cellular localization.
Regulation of histone deacetylase 4 by binding of 14-3-3 proteins.
Regulation of skeletal myogenesis by association of the MEF2 transcription factor with class II histone deacetylases.
The orphan nuclear receptor TR2 interacts directly with both class I and class II histone deacetylases.
Differential localization of HDAC4 orchestrates muscle differentiation.
Enzymatic activity associated with class II HDACs is dependent on a multiprotein complex containing HDAC3 and SMRT/N-CoR.
The histone deacetylase 9 gene encodes multiple protein isoforms.
Class II histone deacetylases: versatile regulators.
Comprehensive proteomic analysis of interphase and mitotic 14-3-3-binding proteins.
Functional interaction between class II histone deacetylases and ICP0 of herpes simplex virus type 1.
Proteomic, functional, and domain-based analysis of in vivo 14-3-3 binding proteins involved in cytoskeletal regulation and cellular organization.
PC4 coactivates MyoD by relieving the histone deacetylase 4-mediated inhibition of myocyte enhancer factor 2C.
Targeted proteomic analysis of 14-3-3 sigma, a p53 effector commonly silenced in cancer.
Identification of the ankyrin repeat proteins ANKRA and RFXANK as novel partners of class IIa histone deacetylases.
Analysis of BCL6-interacting proteins by tandem mass spectrometry.
Regulation of MEF2 by histone deacetylase 4- and SIRT1 deacetylase-mediated lysine modifications.
Class II histone deacetylases confer signal responsiveness to the ankyrin-repeat proteins ANKRA2 and RFXANK.
CaM kinase II selectively signals to histone deacetylase 4 during cardiomyocyte hypertrophy.
Breast cancer metastasis suppressor 1 (BRMS1) is stabilized by the Hsp90 chaperone.
Class II HDACs mediate CaMK-dependent signaling to NRSF in ventricular myocytes.
Epstein-Barr nuclear antigen leader protein coactivates transcription through interaction with histone deacetylase 4.
Parallel SUMOylation-dependent pathways mediate gene- and signal-specific transrepression by LXRs and PPARgamma.
Large-scale mapping of human protein-protein interactions by mass spectrometry.
Crystal structure of a conserved N-terminal domain of histone deacetylase 4 reveals functional insights into glutamine-rich domains.
Sumoylation of the zinc finger protein ZXDC enhances the function of its transcriptional activation domain.
A novel tandem affinity purification strategy for the efficient isolation and characterisation of native protein complexes.
PP2A regulates HDAC4 nuclear import.
Impaired placental trophoblast lineage differentiation in Alkbh1(-/-) mice.
Structural and functional analysis of the human HDAC4 catalytic domain reveals a regulatory structural zinc-binding domain.
HDAC4 represses p21(WAF1/Cip1) expression in human cancer cells through a Sp1-dependent, p53-independent mechanism.
Transcriptional activation of hypoxia-inducible factor-1alpha by HDAC4 and HDAC5 involves differential recruitment of p300 and FIH-1.
FOXP3 up-regulates p21 expression by site-specific inhibition of histone deacetylase 2/histone deacetylase 4 association to the locus.
Activation of ROS/NF-kappaB and Ca2+/CaM kinase II are necessary for VCAM-1 induction in IL-1beta-treated human tracheal smooth muscle cells.
JNK-ATF-2 inhibits thrombomodulin (TM) expression by recruiting histone deacetylase4 (HDAC4) and forming a transcriptional repression complex in the TM promoter.
A human MAP kinase interactome.
Inhibition of androgen receptor activity by histone deacetylase 4 through receptor SUMOylation.
Toward an understanding of the protein interaction network of the human liver.
Sequence-specific recognition of a PxLPxI/L motif by an ankyrin repeat tumbler lock.
The functional interactome landscape of the human histone deacetylase family.
Involvement of Epac1/Rap1/CaMKI/HDAC5 signaling cascade in the regulation of placental cell fusion.
Runx3 inactivation is a crucial early event in the development of lung adenocarcinoma.
Protein interaction network of the mammalian Hippo pathway reveals mechanisms of kinase-phosphatase interactions.
Differential regulation of estrogen receptor α expression in breast cancer cells by metastasis-associated protein 1.
A proteome-scale map of the human interactome network.
Epigenetic changes as a common trigger of muscle weakness in congenital myopathies.
A human interactome in three quantitative dimensions organized by stoichiometries and abundances.
ARD1-mediated Hsp70 acetylation balances stress-induced protein refolding and degradation.
Architecture of the human interactome defines protein communities and disease networks.
Histone deacetylase 4 promotes type I interferon signaling, restricts DNA viruses, and is degraded via vaccinia virus protein C6.
Missense substitutions at a conserved 14-3-3 binding site in HDAC4 cause a novel intellectual disability syndrome.
Dual proteome-scale networks reveal cell-specific remodeling of the human interactome.
OpenCell: Endogenous tagging for the cartography of human cellular organization.
A central chaperone-like role for 14-3-3 proteins in human cells.
Systematic identification of post-transcriptional regulatory modules.
Multimodal cell maps as a foundation for structural and functional genomics.
SUMO E3 ligases SUMOylate target proteins
RANBP2 SUMOylates HDAC4 with SUMO1
RANBP2 SUMOylates HDAC4 with SUMO2,3
HDAC4 SUMOylates NR1H2 (LXRbeta) with SUMO2,3
HDAC4 SUMOylates NR1H3 (LXRalpha) with SUMO2,3
CCND1 recruits HDAC4 to RUNX3