Gene Ontology annotation through association of InterPro records with GO terms

Annotation inferences using phylogenetic trees

Gene Ontology annotation based on UniProtKB/Swiss-Prot Subcellular Location vocabulary mapping

Electronic Gene Ontology annotations created by ARBA machine learning models

Human signal recognition particle (SRP) Alu-associated protein also binds Alu interspersed repeat sequence RNAs. Characterization of human SRP9.

SRP9 with SRP14 (SRP9/14) is the Alu RNA-binding protein that binds the Alu region of 7SL RNA and regulates translational elongation of ribosomes engaged by SRP.

PMID:17154533

Compartmentalization directs assembly of the signal recognition particle.

Describes compartmentalized (nucleolar/cytoplasmic) assembly of SRP, of which SRP9 is a subunit.

PMID:24965446

Host factors that interact with the pestivirus N-terminal protease, Npro, are components of the ribonucleoprotein complex.

PMID:25910212

Widespread macromolecular interaction perturbations in human genetic disorders.

PMID:28514442

Architecture of the human interactome defines protein communities and disease networks.

PMID:30021884

Histone Interaction Landscapes Visualized by Crosslinking Mass Spectrometry in Intact Cell Nuclei.

PMID:32296183

A reference map of the human binary protein interactome.

PMID:32814053

Interactome Mapping Provides a Network of Neurodegenerative Disease Proteins and Uncovers Widespread Protein Aggregation in Affected Brains.

PMID:33961781

Dual proteome-scale networks reveal cell-specific remodeling of the human interactome.

PMID:34208095

SRPassing Co-translational Targeting: The Role of the Signal Recognition Particle in Protein Targeting and mRNA Protection.

SRP9 and SRP14 form the Alu domain of SRP and function in elongation arrest, positioning near the ribosomal elongation-factor binding site to pause translation; signal-sequence recognition is performed by SRP54.

PMID:35271311

OpenCell: Endogenous tagging for the cartography of human cellular organization.

PMID:40205054

Multimodal cell maps as a foundation for structural and functional genomics.

Reactome:R-HSA-1799332

Reactome: Nascent polypeptide:mRNA:ribosome complex binds signal recognition particle (SRP)

PMID:26585389

Retrotransposition and Crystal Structure of an Alu RNP in the Ribosome-Stalling Conformation.

2.0 A crystal structure of the human Alu RNP (SRP9/14 bound to Alu RNA) in the ribosome-stalling conformation; SRP9/14 clamps the Alu RNA and docks at the ribosomal elongation-factor binding site, and mutations weakening the SRP9/14-RNA interface abolish Alu retrotransposition.

PMID:37156570

Nuclear SRP9/SRP14 heterodimer transcriptionally regulates 7SL and BC200 RNA expression.

SRP9/14 localizes substantially in the nucleus; siRNA knockdown selectively reduces the Alu-like Pol III transcripts 7SL (RN7SL1) and BC200 (BCYRN1) by decreasing Pol III occupancy at these loci rather than altering RNA stability, defining a noncanonical nuclear transcriptional role for SRP9/14.

PMID:37309897

Alu RNA fold links splicing with signal recognition particle proteins.

SRP9/14 binds compact (closed) Alu RNA conformations and modulates inclusion of Alu-derived exons, with RNA structure (closed vs open Alu fold) predicting exon inclusion; demonstrates a noncanonical SRP9/14 role in pre-mRNA splicing regulation.

PMID:38858088

The nucleolar phase of signal recognition particle assembly.

SRP proteins (including SRP9/14) associate with many nucleolar and ribosome-biogenesis factors; GFP-SRP9 appears mostly nuclear with faint cytoplasmic staining, and nucleolar integrity is required for proper SRP protein localization, supporting a nucleolar phase of SRP assembly.

PMID:39563162

The role of SRP9/SRP14 in regulating Alu RNA.

Reviews SRP9/14 regulation of Alu-family RNAs (maturation, trafficking, splicing, retrotransposition, transcription); primate SRP9/14 is present at ~20-fold molar excess over assembled SRP and binds 7SL with sub-nanomolar affinity, enabling extensive extra-canonical Alu-RNA regulation.

PMID:38847231

Significance of signal recognition particle 9 nuclear translocation: implications for pancreatic cancer prognosis and functionality.

In resected pancreatic cancer, higher SRP9 nuclear staining is associated with improved recurrence-free survival; SRP9 nuclear translocation is modulated by amino-acid/nutrient status.

file:human/SRP9/SRP9-uniprot.txt

UniProt entry P49458 (SRP9_HUMAN), Signal recognition particle 9 kDa protein

SRP9 is a subunit of the SRP ribonucleoprotein (7SL RNA + six proteins); with SRP14 and the Alu portion of the SRP RNA it forms the elongation-arrest domain; binds RNA as the SRP9/SRP14 heterodimer; cytoplasmic.