Gene Ontology annotation through association of InterPro records with GO terms
Annotation inferences using phylogenetic trees
Gene Ontology annotation based on UniProtKB/Swiss-Prot Subcellular Location vocabulary mapping, accompanied by conservative changes to GO terms applied by UniProt
Gene Ontology annotation based on curation of immunofluorescence data
Automatic transfer of experimentally verified manual GO annotation data to orthologs using Ensembl Compara
Gene Ontology annotation of human sequence-specific DNA binding transcription factors (DbTFs) based on the TFClass database
Combined Automated Annotation using Multiple IEA Methods
Vgl-4, a novel member of the vestigial-like family of transcription cofactors, regulates alpha1-adrenergic activation of gene expression in cardiac myocytes.
TEAD mediates YAP-dependent gene induction and growth control.
TEAD transcription factors mediate the function of TAZ in cell growth and epithelial-mesenchymal transition.
Structural insights into the YAP and TEAD complex.
The Hippo pathway in organ size control, tissue regeneration and stem cell self-renewal.
Regulation of the Hippo-YAP pathway by G-protein-coupled receptor signaling.
Protein interaction network of the mammalian Hippo pathway reveals mechanisms of kinase-phosphatase interactions.
Hippo signaling regulates microprocessor and links cell-density-dependent miRNA biogenesis to cancer.
Mutant Gq/11 promote uveal melanoma tumorigenesis by activating YAP.
Targeting Hippo pathway by specific interruption of YAP-TEAD interaction using cyclic YAP-like peptides.
AMPK modulates Hippo pathway activity to regulate energy homeostasis.
Cellular energy stress induces AMPK-mediated regulation of YAP and the Hippo pathway.
Aerobic glycolysis tunes YAP/TAZ transcriptional activity.
miR-222/VGLL4/YAP-TEAD1 regulatory loop promotes proliferation and invasion of gastric cancer cells.
Genome-wide association between YAP/TAZ/TEAD and AP-1 at enhancers drives oncogenic growth.
Impact of cytosine methylation on DNA binding specificities of human transcription factors.
Architecture of the human interactome defines protein communities and disease networks.
Dual proteome-scale networks reveal cell-specific remodeling of the human interactome.
Human transcription factor protein interaction networks.
The alanyl-tRNA synthetase AARS1 moonlights as a lactyltransferase to promote YAP signaling in gastric cancer.
Both a ubiquitous factor mTEF-1 and a distinct muscle-specific factor bind to the M-CAT motif of the myosin heavy chain beta gene.
Molecular interactions between Vestigial and Scalloped promote wing formation in Drosophila.
RUNX3 binds TEADs and YAP1
TEADs:YAP1 binds CTGF gene
EGR2, SOX10 and TEAD1 bind enhancers in the PMP22 gene
YAP1/TAZ binding to CD274 gene
Premetazoan origin of the hippo signaling pathway.
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The Capsaspora Scalloped/TEAD ortholog (Co-Sd) and Yorkie ortholog (Co-Yki) co-immunoprecipitate and together activate a Hippo-responsive reporter when expressed in Drosophila S2R+ cells.
"epitope-tagged Co-Sd and Co-Yki immunoprecipitated with each other in Drosophila S2R+ cells (Figure 4A), demonstrating their ability to form a protein complex."
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Unicellular holozoan Sd/TEAD homologs retain the C-terminal tyrosine (human TEAD1 Y406) required for YAP-TEAD interaction.
"Indeed, these holozoan species contain homologues of Sd/TEAD with the C-terminal Y460 residue known to be important for YAP-TEAD interaction"
Assembling a Hippo: the evolutionary emergence of an animal developmental signaling pathway.
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TEA-domain factors occur in fungi as well as animals and appear to predate Yorkie; the review proposes that TEAD and the Hippo-Warts kinase module were initially unlinked and were joined by the holozoan novelty Yorkie.
"The fact that Sd/TEAD apparently predates Yorkie in evolutionary history suggests a model in which the Hippo-Warts kinase module and a TEAD transcription factor functioned in unlinked signaling modules"
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Whether choanoflagellate Yorkie orthologs bind Sd/TEAD is unresolved, because their TEAD-binding helices are poorly conserved.
"The degree to which choanoflagellate Yorkie orthologs interact with Sd/TEAD proteins is therefore currently unclear"
The Hippo kinase cascade regulates a contractile cell behavior and cell density in a close unicellular relative of animals.
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In Capsaspora, phenotypes of hyperactive coYki require the residue aligned with YAP1 F95 (TEAD-binding), implying a TEAD-dependent transcriptional output in a unicellular holozoan.
"We found that, in contrast to coYki 4SA, the expression of a coYki 4SA F123A mutant did not affect cell or aggregate morphology (Figure 7)."
UniProtKB record for human TEAD1 (P28347)