Gene Ontology annotation through association of InterPro records with GO terms
Annotation inferences using phylogenetic trees
Gene Ontology annotation based on UniProtKB/Swiss-Prot Subcellular Location vocabulary mapping, accompanied by conservative changes to GO terms applied by UniProt
Automatic Gene Ontology annotation based on Rhea mapping
YeastPathways to GO-CAM conversion
Synthesis of diphosphoinositol pentakisphosphate by a newly identified family of higher inositol polyphosphate kinases.
The inositol hexakisphosphate kinase family. Catalytic flexibility and function in yeast vacuole biogenesis.
In Saccharomyces cerevisiae, the inositol polyphosphate kinase activity of Kcs1p is required for resistance to salt stress, cell wall integrity, and vacuolar morphogenesis.
Global analysis of protein localization in budding yeast.
Plc1p, Arg82p, and Kcs1p, enzymes involved in inositol pyrophosphate synthesis, are essential for phosphate regulation and polyphosphate accumulation in Saccharomyces cerevisiae.
A conserved family of enzymes that phosphorylate inositol hexakisphosphate.
Regulation of inositol metabolism is fine-tuned by inositol pyrophosphates in Saccharomyces cerevisiae.
UniProtKB/Swiss-Prot entry for KCS1 (Q12494)
SGD gene description for KCS1 (yeast)
Inositol pyrophosphates regulate RNA polymerase I-mediated rRNA transcription in Saccharomyces cerevisiae.
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The rate of rRNA synthesis is reduced in kcs1 cells.
"The rate of rRNA synthesis, the first step of ribosome biogenesis, is decreased in kcs1Δ yeast strains, suggesting that RNA polymerase I (Pol I) activity may be reduced in these cells."
The yeast AMP-activated protein kinase Snf1 phosphorylates the inositol polyphosphate kinase Kcs1.
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Snf1 directly phosphorylates Kcs1 at Ser537 and Ser646.
"By in vitro analysis, Snf1 directly phosphorylates Kcs1, predominantly at amino acids 537 and 646."