GO_REF:0000002

Gene Ontology annotation through association of InterPro records with GO terms

GO_REF:0000033

Annotation inferences using phylogenetic trees

GO_REF:0000107

Automatic transfer of experimentally verified manual GO annotation data to orthologs using Ensembl Compara

GO_REF:0000120

Combined Automated Annotation using Multiple IEA Methods

PMID:11015200

Mapping the functional domains of elongation factor-2 kinase.

EEF2K is an alpha-kinase that phosphorylates eEF2 (KM ~1.2 uM); calmodulin binding is strictly required for activity.

PMID:23184662

Phosphorylation of eukaryotic elongation factor 2 (eEF2) by cyclin A-cyclin-dependent kinase 2 regulates its inhibition by eEF2 kinase.

eEF2K phosphorylates eEF2 on Thr56, inactivating it; CDK2 phosphorylates eEF2 on Ser595, which regulates Thr56 phosphorylation by eEF2K during the cell cycle.

PMID:9144159

Identification of a new class of protein kinases represented by eukaryotic elongation factor-2 kinase.

eEF-2 kinase defines a new class of protein kinases (alpha-kinases) structurally unrelated to the conventional eukaryotic protein-kinase superfamily, homologous to myosin heavy chain kinase A.

Reactome:R-HSA-165758

Reactome pathway involving EEF2K (cytosolic localization)