Gene Ontology annotation based on UniProtKB/Swiss-Prot Subcellular Location vocabulary mapping, accompanied by conservative changes to GO terms applied by UniProt
UniProtKB entry A0A1B0GVT2 (SIM36_HUMAN), Small integral membrane protein 36
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Single predicted helical transmembrane segment near the N-terminus.
"FT TRANSMEM 14..34"
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C-terminal region predicted to be disordered.
"FT REGION 73..93"
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Defines its own protein family.
"DR InterPro; IPR063159; SMIM36."
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RNA expression is enriched in retina and testis.
"DR HPA; ENSG00000261873; Group enriched (retina, testis)."
A Genome-Wide Association Study in Psoriasis Patients Reveals Variants Associated with Response to Treatment with Interleukin-17A Pathway Inhibitors.
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An intronic SMIM36 variant is associated with treatment response, but the authors attribute its likely effect to expression of the neighbouring MMD gene.
"rs9914970, an intronic variant in SMIM36, has been identified as eQTL for the nearby (~34 Kb) MMD gene in whole blood"