Gene Ontology annotation through association of InterPro records with GO terms

Automatic assignment of GO terms using logical inference, based on on inter-ontology links

TreeGrafter-generated GO annotations

TNF receptor 1 genetic risk mirrors outcome of anti-TNF therapy in multiple sclerosis.

Crystal structure of the soluble human 55 kd TNF receptor-human TNF beta complex: implications for TNF receptor activation.

The four-domain TNFR1 ectodomain binds in the groove between adjacent TNF-beta subunits.

"The receptor fragment, a very elongated end to end assembly of four similar folding domains, binds in the groove between two adjacent TNF beta subunits."

file:EQUAS/TNFRSF1A/TNFRSF1A-bioinformatics/human_P19438-uniprot.txt

UniProtKB Swiss-Prot record P19438 (human TNFRSF1A), fetched 2026-10-14

file:EQUAS/TNFRSF1A/TNFRSF1A-bioinformatics/RESULTS.md

TNFRSF1A: donkey-human sequence comparison

file:EQUAS/TNFRSF1A/TNFRSF1A-uniprot.txt

UniProtKB record A0A9L0JKX4 (donkey TNFRSF1A)

file:EQUAS/TNFRSF1A/TNFRSF1A-bioinformatics/RESULTS-rereview.md

TNFRSF1A (donkey): comparison of the two gene models

A0A9L0JKX4 is the exon-3-skipping alternative transcript product of the donkey TNFRSF1A gene; otherwise identical to the canonical 453-aa product A0A8C4MD74.

"The 410-aa transcript lacks exactly one exon of the canonical transcript: exon 3 (ENSEASE00005153555, 129 nt = 43 codons, in frame)."