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AmpC is a class C beta-lactamase that hydrolyzes penicillins and cephalosporins
"AmpC belongs to Ambler class C beta-lactamases (EC 3.5.2.6) that hydrolyze the beta-lactam ring of penicillins and cephalosporins"
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AmpC is localized to the periplasm
"AmpC is synthesized with an N-terminal signal peptide, exported across the inner membrane, and localized to the periplasm where it can intercept incoming beta-lactams"
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AmpC expression is induced by indole in P. putida KT2440
"Exogenous indole elevates ampC expression and beta-lactamase activity and increases the proportion of ampicillin-resistant P. putida KT2440 cells"
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AmpC confers resistance to beta-lactam antibiotics
"Hydrolysis of beta-lactam bonds in penicillins, cephalosporins, and monobactams is the signature activity of class C enzymes, conferring resistance when produced at elevated levels"