Annotation inferences using phylogenetic trees
Gene Ontology annotation based on UniProtKB/Swiss-Prot Subcellular Location vocabulary mapping, accompanied by conservative changes to GO terms applied by UniProt
Gene Ontology annotation based on curation of immunofluorescence data
Automatic transfer of experimentally verified manual GO annotation data to orthologs using Ensembl Compara
Combined Automated Annotation using Multiple IEA Methods
Towards a proteome-scale map of the human protein-protein interaction network.
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High-throughput yeast two-hybrid interactome map; source of bare protein binding annotations for CHIC2 with no specific functional partner established.
"Towards a proteome-scale map of the human protein-protein interaction network."
An empirical framework for binary interactome mapping.
A proteome-scale map of the human interactome network.
Network-based prediction of protein interactions.
A reference map of the human binary protein interactome.
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HuRI reference binary interactome; contributes the bulk of CHIC2's high-throughput Y2H interactors, dominated by promiscuous preys.
"A reference map of the human binary protein interactome."
A new family of small, palmitoylated, membrane-associated proteins, characterized by the presence of a cysteine-rich hydrophobic motif.
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The original CHIC2 family paper established that the CHIC motif cysteines are palmitoylated and that CHIC2 associates with vesicular structures and the plasma membrane.
"Our data illustrate that cysteines in this central CHIC motif are palmitoylated and that CHIC2 is associated with vesicular structures and the plasma membrane."
A STUB1-CHIC2 complex inhibits CD8(+) T cells to restrain tumor immunity.
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CHIC2 physically and functionally partners with STUB1 as an adapter that regulates cytokine receptor expression in mouse and human CD8+ T cells.
"Mechanistically, STUB1 interacts with the adapter protein CHIC2 to regulate cytokine receptor expression in mouse and human CD8+ T cells."
UniProt entry CHIC2_HUMAN (Q9UKJ5)
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Documents CHIC2 subcellular localization (cell membrane, cytoplasmic vesicle, Golgi-like vesicular compartment), palmitoylation in the CHIC motif required for membrane association, and the t(4;12) translocation with ETV6.
"SUBCELLULAR LOCATION; Cell membrane {ECO:0000269|PubMed:11257495}. Cytoplasmic vesicle {ECO:0000269|PubMed:11257495}."