Gene Ontology annotation through association of InterPro records with GO terms
Manual transfer of experimentally-verified manual GO annotation data to orthologs by curator judgment of sequence similarity
Annotation inferences using phylogenetic trees
Gene Ontology annotation based on UniProtKB/Swiss-Prot Subcellular Location vocabulary mapping, accompanied by conservative changes to GO terms applied by UniProt
Automatic transfer of experimentally verified manual GO annotation data to orthologs using Ensembl Compara
Automatic assignment of GO terms using logical inference, based on on inter-ontology links
Electronic Gene Ontology annotations created by ARBA machine learning models
Drosophila Topors is a RING finger-containing protein that functions as a ubiquitin-protein isopeptide ligase for the hairy basic helix-loop-helix repressor protein.
Novel small GTPase subfamily capable of associating with tubulin is required for chromosome segregation.
Integral and associated lysosomal membrane proteins.
Large-scale proteomics and phosphoproteomics of urinary exosomes.
Defining the membrane proteome of NK cells.
Exploration of panviral proteome: high-throughput cloning and functional implications in virus-host interactions.
A proteome-scale map of the human interactome network.
BORC, a multisubunit complex that regulates lysosome positioning.
The Rab7 effector PLEKHM1 binds Arl8b to promote cargo traffic to lysosomes.
A reference map of the human binary protein interactome.
Dual proteome-scale networks reveal cell-specific remodeling of the human interactome.
RUFY3 and RUFY4 are ARL8 effectors that promote coupling of endolysosomes to dynein-dynactin.
Multimodal cell maps as a foundation for structural and functional genomics.
BORC Functions Upstream of Kinesins 1 and 3 to Coordinate Regional Movement of Lysosomes along Different Microtubule Tracks.
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BORC and ARL8 act upstream of both kinesin-1 (KIF5B) and kinesin-3 (KIF1A/KIF1Bbeta), which move lysosomes on distinct microtubule tracks (KIF5B on central acetylated tubulin, KIF1A/KIF1Bbeta on peripheral tyrosinated tubulin); in an ARL8B-knockout background, siRNA against ARL8A removes the residual ability of kinesin constructs to disperse lysosomes, indicating ARL8A itself contributes to BORC-dependent anterograde lysosome transport.
BORC-ARL8-HOPS ensemble is required for lysosomal cholesterol egress through NPC2.
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The BORC-ARL8-HOPS ensemble is required for egress of free cholesterol from lysosomes; depletion of BORC, ARL8, or HOPS causes lysosomal free-cholesterol accumulation, decreased NPC2 association with lysosomes with increased NPC2 secretion, and increased lysosomal degradation of the CI-mannose-6-phosphate receptor.
Inhibition of endolysosome fusion increases exosome secretion.
DENND6A links Arl8b to a Rab34/RILP/dynein complex, regulating lysosomal positioning and autophagy.
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DENND6A is an ARL8B effector and GEF that activates Rab34 to recruit a RILP/dynein-dynactin complex, driving retrograde (juxtanuclear) lysosome transport and supporting autophagic flux; double knockdown of ARL8A and ARL8B reduces DENND6A-dependent phenotypes, consistent with an ARL8-family contribution.
Biallelic BORCS8 variants cause an infantile-onset neurodegenerative disorder with altered lysosome dynamics.
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Biallelic loss-of-function variants in the BORC subunit BORCS8 (which acts upstream of ARL8 to recruit kinesin motors for anterograde lysosome transport) cause a severe early-infantile neurodegenerative disorder in five children; patient alleles impair BORC assembly and peripheral lysosome distribution, validating the BORC-ARL8-kinesin axis physiologically in humans.
Altered expression of vesicular trafficking machinery in prostate cancer affects lysosomal dynamics and provides insight into the underlying biology and disease progression.
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In prostate cancer cohorts, altered expression of lysosomal trafficking machinery including ARL8A was examined; ARL8A expression showed only a non-significant association with overall survival (log-rank P=0.1471, HR 1.927, 95% CI 0.6692-5.547).
Exocytosis of azurophil granule membrane proteins
Exocytosis of ficolin-rich granule membrane proteins
An N-terminally acetylated Arf-like GTPase is localised to lysosomes and affects their motility.
UniProtKB record for human ARL8A
ARL8A PN-context review notes
PN projected new-to-GOA annotations report
PN mapping scrutiny report