ADK1 (AKY2, YDR226W, P07170) notes

• Major ATP:AMP adenylate kinase, AK2 subfamily [UniProt:P07170 "Reaction=AMP + ATP = 2 ADP"]; [UniProt:P07170 "Belongs to the adenylate kinase family. AK2 subfamily."].
• Dual localisation cytosol (~90%) + mitochondrial IMS (~10%), no cleavable presequence PMID:2850178; PMID:12045196.
• Null: viable, slow, pet; ~10% residual cytosolic activity from a minor cytoplasmic isozyme PMID:2850178; PMID:2848829; ts at 37C PMID:20659900.
• Catalytic activity required for PHO/ADE regulon control PMID:18433446.
• Structures with Ap5A / ATP analogue PMID:7670369, PMID:8594191.
• Moonlighting: chromatin/Orc3 binding, pre-RC assembly PMID:20659900; origin association by ChIP only PMID:20659900 -> origin DNA binding MF marked over-annotated.
• YeastPathways "adenosine ribonucleotides de novo biosynthesis" mapped to GO "adenosine biosynthetic process" (nucleoside) -- mapping error, removed.