Gene Ontology annotation through association of InterPro records with GO terms
Annotation inferences using phylogenetic trees
Gene Ontology annotation based on UniPathway vocabulary mapping
Gene Ontology annotation based on UniProtKB/Swiss-Prot Subcellular Location vocabulary mapping, accompanied by conservative changes to GO terms applied by UniProt
Electronic Gene Ontology annotations created by ARBA machine learning models
UniProtKB entry STAR_HUMAN (P49675)
The steroidogenic acute regulatory protein, StAR, works only at the outer mitochondrial membrane.
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Indexed as review articles. Their abstracts summarize compartment-targeted STAR constructs/transport evidence; cited experimental GO rows are preserved, while new primary support comes from PMID12372832 and7761400. Do not assert that TSPO is obligatorily required from the historical model.
"Only the constructs at the OMM were active, either in vivo or in vitro."
Steroidogenic acute regulatory protein (StAR), a novel mitochondrial cholesterol transporter.
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Indexed as review articles. Their abstracts summarize compartment-targeted STAR constructs/transport evidence; cited experimental GO rows are preserved, while new primary support comes from PMID12372832 and7761400. Do not assert that TSPO is obligatorily required from the historical model.
"outer to inner mitochondrial membrane, but acts exclusively on the outer"
Intracellular cholesterol transporter StarD4 binds free cholesterol and increases cholesteryl ester formation.
A proteome-scale map of the human interactome network.
Widespread macromolecular interaction perturbations in human genetic disorders.
Widespread Expansion of Protein Interaction Capabilities by Alternative Splicing.
A reference map of the human binary protein interactome.
Interactome Mapping Provides a Network of Neurodegenerative Disease Proteins and Uncovers Widespread Protein Aggregation in Affected Brains.
Quantitative high-confidence human mitochondrial proteome and its dynamics in cellular context.
Human steroidogenic acute regulatory protein: functional activity in COS-1 cells, tissue-specific expression, and mapping of the structural gene to 8p11.2 and a pseudogene to chromosome 13.
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Human STAR functional-expression or patient-variant evidence. Adrenal and gonadal roles are supported; the expression study specifically did not detect placental STAR transcript, so STAR-dependent delivery is not universal across steroidogenic tissues.
"Human StAR, coexpressed in COS-1 cells with cytochrome P450scc and adrenodoxin, increased pregnenolone synthesis > 4-fold."
Role of steroidogenic acute regulatory protein in adrenal and gonadal steroidogenesis.
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Human STAR functional-expression or patient-variant evidence. Adrenal and gonadal roles are supported; the expression study specifically did not detect placental STAR transcript, so STAR-dependent delivery is not universal across steroidogenic tissues.
"In three unrelated individuals with this disorder, steroidogenic acute regulatory protein, which enhances the mitochondrial conversion of cholesterol into pregnenolone, was mutated and nonfunctional"
Pregnenolone biosynthesis
STAR mediates CHOL translocation from cytosol to mitochondrial intermembrane space
LONP1 degrades mitochondrial matrix proteins
LONP1 binds mitochondrial matrix proteins
AFG3L2 degrades mitochondrial matrix proteins
AFG3L2 binds mitochondrial matrix proteins
Transfer of cholesterol between phospholipid vesicles mediated by the steroidogenic acute regulatory protein (StAR).