PMID:10521921

A novel human stress response-related gene with a potential role in induced radioresistance.

FKBPL is a stress-response-related gene with a potential role in induced radioresistance.

PMID:25036637

A quantitative chaperone interaction network reveals the architecture of cellular protein homeostasis pathways.

PMID:25416956

A proteome-scale map of the human interactome network.

PMID:25767277

FKBPL is a critical antiangiogenic regulator of developmental and pathological angiogenesis.

FKBPL is detected in the extracellular region and acts as a secreted anti-angiogenic factor.

PMID:28514442

Architecture of the human interactome defines protein communities and disease networks.

PMID:32296183

A reference map of the human binary protein interactome.

PMID:33961781

Dual proteome-scale networks reveal cell-specific remodeling of the human interactome.

BioPlex affinity-purification interactome capturing an FKBPL-ANKRD49 interaction.

PMID:40205054

Multimodal cell maps as a foundation for structural and functional genomics.

Reactome:R-HSA-8852362

Reactome: FKBPL in cytosol.

file:human/FKBPL/FKBPL-uniprot.txt

UniProt entry Q9UIM3 (FKBPL_HUMAN), FK506-binding protein-like / WISp39

TPR-containing FKBP-like protein lacking a catalytic PPIase domain; regulates p21 (CDKN1A) protein stability by binding HSP90 and p21 and forming a ternary HSP90AB1/p21 complex; may be involved in the response to X-ray; ubiquitously expressed (highest in testis).

file:human/FKBPL/FKBPL-deep-research-falcon.md

Falcon deep research report for FKBPL

FKBPL is a divergent FKBP-family immunophilin that lacks significant peptidyl-prolyl cis-trans isomerase activity and acts as a non-enzymatic scaffold/co-chaperone; intracellularly it is Hsp90-associated and stabilizes p21 (CDKN1A), while a secreted pool acts extracellularly as an anti-angiogenic factor targeting CD44.
A 2024 study reports a novel cytosolic FKBPL function in ER-phagy and protein secretion, in which FKBPL interacts with the ER-resident transmembrane protein CKAP4 and bridges it to LC3/GABARAP autophagy machinery via LIR motifs.