Gene Ontology annotation through association of InterPro records with GO terms
Manual transfer of experimentally-verified manual GO annotation data to orthologs by curator judgment of sequence similarity
Gene Ontology annotation based on UniProtKB/Swiss-Prot Subcellular Location vocabulary mapping, accompanied by conservative changes to GO terms applied by UniProt
Gene Ontology annotation based on curation of immunofluorescence data
Automatic transfer of experimentally verified manual GO annotation data to orthologs using Ensembl Compara
Gene Ontology annotations Inferred by Curator (IC) using at least one Inferred by Sequence Similarity (ISS) annotation to support the inference
Combined Automated Annotation using Multiple IEA Methods
The small GTPase RalA targets filamin to induce filopodia.
Binding of paxillin to alpha4 integrins modifies integrin-dependent biological responses.
Modulation of dopamine D(2) receptor signaling by actin-binding protein (ABP-280).
Filamin A and Filamin B are co-expressed within neurons during periods of neuronal migration and can physically interact.
A proteomics strategy to elucidate functional protein-protein interactions applied to EGF signaling.
Large-scale identification and characterization of human genes that activate NF-kappaB and MAPK signaling pathways.
Interaction between the mu opioid receptor and filamin A is involved in receptor regulation and trafficking.
FOXC1 transcriptional regulatory activity is impaired by PBX1 in a filamin A-mediated manner.
The Z-disc proteins myotilin and FATZ-1 interact with each other and are connected to the sarcolemma via muscle-specific filamins.
CEACAM1 functionally interacts with filamin A and exerts a dual role in the regulation of cell migration.
The structure of the GPIb-filamin A complex.
FilGAP, a Rho- and ROCK-regulated GAP for Rac binds filamin A to control actin remodelling.
Cyclin B1/Cdk1 binds and phosphorylates Filamin A and regulates its ability to cross-link actin.
Systematic identification of SH3 domain-mediated human protein-protein interactions by peptide array target screening.
Roles of protein kinase C and actin-binding protein 280 in the regulation of intracellular trafficking of dopamine D3 receptor.
Structure of three tandem filamin domains reveals auto-inhibition of ligand binding.
Filamin A regulates cell spreading and survival via beta1 integrins.
Filamin A stabilizes Fc gamma RI surface expression and prevents its lysosomal routing.
Ligand-sensitive binding of actin-binding protein to immunoglobulin G Fc receptor I (Fc gamma RI).
A B-Myb complex containing clathrin and filamin is required for mitotic spindle function.
Large-scale proteomics and phosphoproteomics of urinary exosomes.
Identification and characterization of multiple similar ligand-binding repeats in filamin: implication on filamin-mediated receptor clustering and cross-talk.
Defining the membrane proteome of NK cells.
LL5beta directs the translocation of filamin A and SHIP2 to sites of phosphatidylinositol 3,4,5-triphosphate (PtdIns(3,4,5)P3) accumulation, and PtdIns(3,4,5)P3 localization is mutually modified by co-recruited SHIP2.
MHC class II-associated proteins in B-cell exosomes and potential functional implications for exosome biogenesis.
A novel interaction between FlnA and Syk regulates platelet ITAM-mediated receptor signaling and function.
Identification of novel nuclear protein interactions with the N-terminal part of filamin A.
Protein profile of exosomes from trabecular meshwork cells.
Analysis of the myosin-II-responsive focal adhesion proteome reveals a role for β-Pix in negative regulation of focal adhesion maturation.
Evidence for multisite ligand binding and stretching of filamin by integrin and migfilin.
Protein interactome reveals converging molecular pathways among autism disorders.
Association of filamin A and vimentin with hepatitis C virus proteins in infected human hepatocytes.
Mechanical strain in actin networks regulates FilGAP and integrin binding to filamin A.
A meckelin-filamin A interaction mediates ciliogenesis.
Cytoskeletal protein filamin A is a nucleolar protein that suppresses ribosomal RNA gene transcription.
Insights into RNA biology from an atlas of mammalian mRNA-binding proteins.
The mRNA-bound proteome and its global occupancy profile on protein-coding transcripts.
Platelet proteome analysis reveals integrin-dependent aggregation defects in patients with myelodysplastic syndromes.
In-depth proteomic analyses of exosomes isolated from expressed prostatic secretions in urine.
Human endothelial actin-binding protein (ABP-280, nonmuscle filamin): a molecular leaf spring.
The cytoplasmic domain of neuropilin-1 regulates focal adhesion turnover.
Functional interaction with filamin A and intracellular Ca2+ enhance the surface membrane expression of a small-conductance Ca2+-activated K+ (SK2) channel.
Using an in situ proximity ligation assay to systematically profile endogenous protein-protein interactions in a pathway network.
Amino- and carboxyl-terminal domains of Filamin-A interact with CRMP1 to mediate Sema3A signalling.
E-cadherin interactome complexity and robustness resolved by quantitative proteomics.
A mechanism of global shape-dependent recognition and phosphorylation of filamin by protein kinase A.
Structural mechanism of integrin inactivation by filamin.
Filamin A is required in injured axons for HDAC5 activity and axon regeneration.
G protein-coupled receptors directly bind filamin A with high affinity and promote filamin phosphorylation.
A human interactome in three quantitative dimensions organized by stoichiometries and abundances.
DND1 maintains germline stem cells via recruitment of the CCR4-NOT complex to target mRNAs.
Histone Interaction Landscapes Visualized by Crosslinking Mass Spectrometry in Intact Cell Nuclei.
Localization of the domain of actin-binding protein that binds to membrane glycoprotein Ib and actin in human platelets.
LPA receptor 1 (LPAR1) is a novel interaction partner of Filamin A that promotes Filamin A phosphorylation, MRTF-A transcriptional activity and oncogene-induced senescence.
Identification of actin-binding protein as the protein linking the membrane skeleton to glycoproteins on platelet plasma membranes.
Filamin binds to the cytoplasmic domain of the beta1-integrin. Identification of amino acids responsible for this interaction.
MigFilin associates with Filamin and F-actin
Release of platelet cytosolic components
RNASEL binds 2'-5' oligoadenylate
Dynamic interactions of Fc gamma receptor IIB with filamin-bound SHIP1 amplify filamentous actin-dependent negative regulation of Fc epsilon receptor I signaling.
Insulin-like growth factor-binding protein-5-induced laminin gamma1 transcription requires filamin A.
A glial origin for periventricular nodular heterotopia caused by impaired expression of Filamin-A.
Distinct regional and subcellular localization of the actin-binding protein filamin A in the mature rat brain.
Filamin A is a regulator of blood-testis barrier assembly during postnatal development in the rat testis.
HCN1 and HCN2 proteins are expressed in cochlear hair cells: HCN1 can form a ternary complex with protocadherin 15 CD3 and F-actin-binding filamin A or can interact with HCN2.
Amotl2 interacts with LL5β, localizes to podosomes and regulates postsynaptic differentiation in muscle.
The Oxygen Sensor PHD2 Controls Dendritic Spines and Synapses via Modification of Filamin A.
FLNA source evidence, context projection and access limits