Gene Ontology annotation through association of InterPro records with GO terms

Gene Ontology annotation based on UniPathway vocabulary mapping

Gene Ontology annotation based on UniProtKB/Swiss-Prot Subcellular Location vocabulary mapping, accompanied by conservative changes to GO terms applied by UniProt

GO_REF:0000120

Combined Automated Annotation using Multiple IEA Methods

GO_REF:0000122

AtSubP analysis

PMID:14690501

Membrane-bound fatty acid desaturases are inserted co-translationally into the ER and contain different ER retrieval motifs at their carboxy termini.

Membrane fatty acid desaturases including FAD2 are co-translationally inserted into the ER membrane and carry C-terminal ER-retrieval motifs.

PMID:1730697

Arabidopsis mutants deficient in polyunsaturated fatty acid synthesis. Biochemical and genetic characterization of a plant oleoyl-phosphatidylcholine desaturase.

Characterizes FAD2 as the plant oleoyl-phosphatidylcholine (acyl-lipid) omega-6 desaturase; fad2 mutants are deficient in polyunsaturated fatty acids.

PMID:8685264

Functional expression of the extraplastidial Arabidopsis thaliana oleate desaturase gene (FAD2) in Saccharomyces cerevisiae.

FAD2 expressed in yeast confers omega-6 (Delta-12) desaturase activity, converting oleate (18:1) to linoleate (18:2).

file:ARATH/FAD2/FAD2-deep-research-falcon.md

Falcon/Edison deep research report for FAD2, Arabidopsis thaliana

Synthesizes FAD2 as the ER omega-6/Delta-12 desaturase acting on PC-esterified oleate via cytochrome b5; central to seed-oil PUFA content and ER membrane unsaturation (ER-stress, cold responses); a canonical high-oleic oilseed engineering target.