Gene Ontology annotation through association of InterPro records with GO terms
Annotation inferences using phylogenetic trees
Automatic transfer of experimentally verified manual GO annotation data to orthologs using Ensembl Compara
Electronic Gene Ontology annotations created by ARBA machine learning models
Combined Automated Annotation using Multiple IEA Methods
The human plasma proteome: a nonredundant list developed by combination of four separate sources.
Defining the membrane proteome of NK cells.
Proteomic analysis of cerebrospinal fluid extracellular vesicles: a comprehensive dataset.
Inactivation of human plasma kallikrein and factor XIa by protein C inhibitor.
Architecture of the human interactome defines protein communities and disease networks.
Dual proteome-scale networks reveal cell-specific remodeling of the human interactome.
Mechanism of inhibition of activated protein C by protein C inhibitor.
Increased tissue factor-initiated prothrombin activation as a result of the Arg506 --> Gln mutation in factor VLEIDEN.
Protein C inhibitor secreted from activated platelets efficiently inhibits activated protein C on phosphatidylethanolamine of platelet membrane and microvesicles.
prothrombin -> activated thrombin (factor IIa) + thrombin activation peptide (prothrombinase catalyst)
factor Va + factor Xa -> Va:Xa complex (prothrombinase)
factor V -> factor Va + factor V activation peptide (thrombin catalyst)
Activated protein C cleaves factor Va to factor Vi intermediate form
SEC31:SEC13 and v-SNARE recruitment
Exocytosis of platelet alpha granule contents
Activated protein C cleaves Factor Va intermediate form for Factor Va
Nucleotide exchange on RAB1
SEC16 complex binds SAR1B:GTP:SEC23:SEC24
RAB1:GTP binds USO1 and GORASP1:GOLGA2
Hexameric LMAN1:MCFD2 bind glycosylated Factor V and VIII precursors
COPII coat binds TRAPPCII and RAB1:GDP
CSNK1D phosphorylates SEC23
BET1:GOSR2:STX5 bind v-SNARES on tethered vesicle
Inner coat assembly and cargo binding
FAM20C phosphorylates FAM20C substrates
Factor Xa inhibitors bind Va:Xa
factor V -> factor Va intermediate + factor V activation peptide (FXa catalyst)
F5 R334T, I387T is not cleaved by activated protein C
F5 R534Q, A540V is not cleaved by activated protein C
factor V -> factor Va intermediate + factor V activation peptide (thrombin catalyst)
factor Va intermediate -> factor Va
TFPIα:FV intermediate:PROS1 binds TF:FVIIa:FXa
TFPIα + FV intermediate + PROS1 => TFPIα:FV intermediate:PROS1
factor Va intermediate + factor Xa -> factor Va intermediate:factor Xa
Coagulation Factor V contains copper ion.
Biosynthetic origin and functional significance of murine platelet factor V.
Fatal haemorrhage and incomplete block to embryogenesis in mice lacking coagulation factor V.
Rescue of fatal neonatal hemorrhage in factor V deficient mice by low level transgene expression.
The murine platelet and plasma factor V pools are biosynthetically distinct and sufficient for minimal hemostasis.
Rat coagulation factors V, VIII, XI, and XII: vitamin K dependent.
Analysis of factor V in zebrafish demonstrates minimal levels needed for early hemostasis.
Characterization of zebrafish coagulation cofactors Fviii and Fv mutants and modeling hemophilia A and factor V deficiency.
A Single Kinase Generates the Majority of the Secreted Phosphoproteome.
Factor V-short and protein S as synergistic tissue factor pathway inhibitor (TFPIα) cofactors.
Characterization of a novel human protein C inhibitor (PCI) gene transgenic mouse useful for studying the role of PCI in physiological and pathological conditions.
UniProt P12259 factor V record