GO_REF:0000002
Gene Ontology annotation through association of InterPro records with GO terms
GO_REF:0000024
Manual transfer of experimentally-verified manual GO annotation data to orthologs by curator judgment of sequence similarity
GO_REF:0000033
Annotation inferences using phylogenetic trees
GO_REF:0000044
Gene Ontology annotation based on UniProtKB/Swiss-Prot Subcellular Location vocabulary mapping, accompanied by conservative changes to GO terms applied by UniProt
GO_REF:0000052
Gene Ontology annotation based on curation of immunofluorescence data
GO_REF:0000107
Automatic transfer of experimentally verified manual GO annotation data to orthologs using Ensembl Compara
GO_REF:0000116
Automatic Gene Ontology annotation based on Rhea mapping
GO_REF:0000117
Electronic Gene Ontology annotations created by ARBA machine learning models
GO_REF:0000120
Combined Automated Annotation using Multiple IEA Methods
PMID:12004135
A complex with chromatin modifiers that occupies E2F- and Myc-responsive genes in G0 cells.
PMID:16702210
Zinc finger protein Wiz links G9a/GLP histone methyltransferases to the co-repressor molecule CtBP.
PMID:19061646
CDYL bridges REST and histone methyltransferases for gene repression and suppression of cellular transformation.
PMID:19144645
Dynamic Histone H1 Isotype 4 Methylation and Demethylation by Histone Lysine Methyltransferase G9a/KMT1C and the Jumonji Domain-containing JMJD2/KDM4 Proteins.
PMID:20118233
G9a and Glp methylate lysine 373 in the tumor suppressor p53.
PMID:20871592
Methyl-H3K9-binding protein MPP8 mediates E-cadherin gene silencing and promotes tumour cell motility and invasion.
PMID:21131967
Lysine methylation of the NF-κB subunit RelA by SETD6 couples activity of the histone methyltransferase GLP at chromatin to tonic repression of NF-κB signaling.
PMID:24196706
EHMT1 controls brown adipose cell fate and thermogenesis through the PRDM16 complex.
PMID:26496610
A human interactome in three quantitative dimensions organized by stoichiometries and abundances.
PMID:29628311
A Family of Vertebrate-Specific Polycombs Encoded by the LCOR/LCORL Genes Balance PRC2 Subtype Activities.
Reactome:R-HSA-3788724
Cdh1:APC/C ubiquitinates EHMT1 and EHMT2
Reactome:R-HSA-3788725
Cdh1:APC/C complex binds EHMT1:EHMT2
Reactome:R-HSA-3788745
EHMT1:EHMT2 methylates IL8 promoter
Reactome:R-HSA-3788748
EHMT1:EHMT2 methylates IL6 promoter
Reactome:R-HSA-5634729
EHMT1:EHMT2 (KMT1D:KMT1C) methylates methyl-lysine-10 of histone H3 (H3K9)
Reactome:R-HSA-5634750
EHMT1:EHMT2 (KMT1D:KMT1C) methylates lysine-10 of histone H3 (H3K9)
Reactome:R-HSA-6805755
EHMT1:EHMT2 dimethylates TP53
Reactome:R-HSA-8953418
EHMT1:EHMT2 complex binds E2F6.com-1 core
Reactome:R-HSA-8953452
E2F6.com-1 complex binds the E2F1 gene promoter
Reactome:R-HSA-9007283
CBX3 and PRC1.6 associate with E2F6.com-1
PMID:15774718
Histone methyltransferases G9a and GLP form heteromeric complexes and are both crucial for methylation of euchromatin at H3-K9.
PMID:18818694
G9a/GLP complexes independently mediate H3K9 and DNA methylation to silence transcription.
PMID:20084102
Structural biology of human H3K9 methyltransferases.
PMID:20434463
Adding a lysine mimic in the design of potent inhibitors of histone lysine methyltransferases.
PMID:22496781
Coexpression of nuclear receptors and histone methylation modifying genes in the testis: implications for endocrine disruptor modes of action.
PMID:24703692
Prdm16 is required for the maintenance of brown adipocyte identity and function in adult mice.
PMID:35978186
Post-translational control of beige fat biogenesis by PRDM16 stabilization.
GO_REF:0000003
Gene Ontology annotation based on Enzyme Commission mapping
https://www.proteinatlas.org/ENSG00000181090-EHMT1/subcellular
Subcellular - EHMT1 - The Human Protein Atlas
file:human/EHMT1/EHMT1-bioinformatics/evidence/RESULTS.md
EHMT1 saved-input evidence replay and results
file:human/EHMT1/EHMT1-source-evidence.yaml
EHMT1 source evidence and access guide
PMID:18264113
The ankyrin repeats of G9a and GLP histone methyltransferases are mono- and dimethyllysine binding modules.