Micropeptide MIAC Inhibits HNSCC Progression by Interacting with Aquaporin 2.
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MIAC is an endogenous micropeptide that binds AQP2 and suppresses the actin cytoskeleton in HNSCC cells.
"Mechanistically, MIAC directly interacts with AQP2 (Aquaporin 2) to inhibit the actin cytoskeleton by regulating SEPT2 (Septin 2)/ITGB4 (Integrin Beta 4) and ultimately suppressing the tumor growth and metastasis of HNSCC."
Micropeptide MIAC inhibits the tumor progression by interacting with AQP2 and inhibiting EREG/EGFR signaling in renal cell carcinoma.
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MIAC with AQP2 lowers EREG/EGFR expression and downstream PI3K/AKT and RAS/ERK activation in renal carcinoma cells.
"Simultaneous overexpression of AQP2 protein and MIAC micropeptide can significantly down-regulate the expression of EREG and EGFR, and inhibiting the activation of downstream signaling pathways PI3K/AKT and RAS/ERK"
UniProt entry A0A7L8Y648 (MIAC_HUMAN)