Gene Ontology annotation through association of InterPro records with GO terms
Annotation inferences using phylogenetic trees
Gene Ontology annotation based on UniProtKB/Swiss-Prot Subcellular Location vocabulary mapping, accompanied by conservative changes to GO terms applied by UniProt
Gene Ontology annotation based on curation of immunofluorescence data
Automatic transfer of experimentally verified manual GO annotation data to orthologs using Ensembl Compara
Electronic Gene Ontology annotations created by ARBA machine learning models
Combined Automated Annotation using Multiple IEA Methods
Effect of G protein heterotrimer composition on coupling of neurotransmitter receptors to N-type Ca(2+) channel modulation in sympathetic neurons.
Evidence for the involvement of Gi2 in activation of extracellular signal-regulated kinases in hepatocytes.
Somatostatin inhibits exocytosis in rat pancreatic alpha-cells by G(i2)-dependent activation of calcineurin and depriming of secretory granules.
Developmental expression of heterotrimeric G-proteins in the murine cerebellar cortex.
G-protein alpha subunit isoforms couple differentially to receptors that mediate presynaptic inhibition at rat hippocampal synapses.
Modulation of G(ialpha(2)) signaling by the axonal guidance molecule UNC5H2.
Proteomic and biochemical analyses of human B cell-derived exosomes. Potential implications for their function and multivesicular body formation.
Overexpression of wild-type Galpha(i)-2 suppresses beta-adrenergic signaling in cardiac myocytes.
Gi2 signaling enhances proliferation of neural progenitor cells in the developing brain.
Towards a proteome-scale map of the human protein-protein interaction network.
mGluR2 acts through inhibitory Galpha subunits to regulate transmission and long-term plasticity at hippocampal mossy fiber-CA3 synapses.
Activation state-dependent interaction between Galphai and p67phox.
Localization of Gi alpha proteins in the centrosomes and at the midbody: implication for their role in cell division.
Agonist-selective signaling is determined by the receptor location within the membrane domains.
Large-scale proteomics and phosphoproteomics of urinary exosomes.
Proteomic analysis of human parotid gland exosomes by multidimensional protein identification technology (MudPIT).
Defining the membrane proteome of NK cells.
MHC class II-associated proteins in B-cell exosomes and potential functional implications for exosome biogenesis.
Identification and experimental validation of G protein alpha inhibiting activity polypeptide 2 (GNAI2) as a microRNA-138 target in tongue squamous cell carcinoma.
Transport of receptors, receptor signaling complexes and ion channels via neuropeptide-secretory vesicles.
Brain heterotrimeric Gαi₂-subunit protein-gated pathways mediate central sympathoinhibition to maintain fluid and electrolyte homeostasis during stress.
The essential role of Giα2 in prostate cancer cell migration.
Differential G protein subunit expression by prostate cancer cells and their interaction with CXCR5.
Proteomic analysis of cerebrospinal fluid extracellular vesicles: a comprehensive dataset.
Using an in situ proximity ligation assay to systematically profile endogenous protein-protein interactions in a pathway network.
A proteome-scale map of the human interactome network.
Lysophosphatidic acid rescues bone mesenchymal stem cells from hydrogen peroxide-induced apoptosis.
Knockdown of Inhibitory Guanine Nucleotide Binding Protein Giα-2 by Antisense Oligodeoxynucleotides Attenuates the Development of Hypertension and Tachycardia in Spontaneously Hypertensive Rats.
A Mutation in the G-Protein Gene GNB2 Causes Familial Sinus Node and Atrioventricular Conduction Dysfunction.
A reference map of the human binary protein interactome.
Dual proteome-scale networks reveal cell-specific remodeling of the human interactome.
OpenCell: Endogenous tagging for the cartography of human cellular organization.
G protein subunit alpha i2's pivotal role in angiogenesis.
Multimodal cell maps as a foundation for structural and functional genomics.
Regulation of cAMP-mediated gene transcription by wild type and mutated G-protein alpha subunits. Inhibition of adenylyl cyclase activity by muscarinic receptor-activated and constitutively activated G(o) alpha.
Distinct patterns of bidirectional regulation of mammalian adenylyl cyclases.
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Purified G alpha effects depend on cyclase isoform and concentration.
"Type II adenylyl cyclase appears to be
immune to inhibition by these proteins"
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High concentrations of Gi alpha activate type I and II adenylyl cyclases through the Gs alpha site.
"High concentrations of Gi alpha can interact with site 1 on types I and II adenylyl cyclase and activate the enzymes."
Insulin action impaired by deficiency of the G-protein subunit G ialpha2.
Right ventricular outflow tract tachycardia due to a somatic cell mutation in G protein subunitalphai2.
Adenylate cyclase increases the GTPase activity of G alpha-olf
G alpha-olf:GTP binds to Gi alpha1:GTP:adenylate cyclase complex
Dissociation of the Gi alpha:G olf complex
Adenylate cyclase increases the GTPase activity of Gi alpha
Liganded Gi-activating GPCR acts as a GEF for Gi
Activated P2Y purinoceptor 12 binds G-protein Gi
Gi activation by P2Y purinoceptor 12
Dissociation of the P2Y purinoceptor 12:Gi complex
The Ligand:GPCR:Gi complex dissociates
Liganded Gi-activating GPCRs bind inactive heterotrimeric G-protein Gi
Inactive G alpha (i) reassociates with G beta:gamma
G protein alpha (i)-SRC complex catalyzes SRC to p-Y419-SRC
G protein alpha (i)-SRC complex dissociates to G protein alpha (i) and Active SRC
G alpha (i):RGS dissociates to inactive G alpha (i)–i1/i2/i3
Active G alpha (i)–i1/i2/i3 binds RGS proteins
G alpha (i)–i1/i2/i3 in G (i):RGS complex is inactivated
G-proteins dissociate from plasma-membrane estrogen receptors
Heterotrimeric G protein (i) binds membrane-associated ESRs:ESTG
UniProtKB record for human GNAI2