Gene Ontology annotation through association of InterPro records with GO terms
Gene Ontology annotation based on Enzyme Commission mapping
Electronic Gene Ontology annotations created by transferring manual GO annotations between related proteins based on shared sequence features
Automatic assignment of GO terms using logical inference, based on on inter-ontology links
Combined Automated Annotation using Multiple IEA Methods
Transport and kinase activities of CbrA of Pseudomonas putida KT2440.
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CbrA autophosphorylates and transfers phosphate to CbrB.
"it is shown that the histidine kinase can autophosphorylate and transfer the phosphoryl group to the response regulator CbrB."
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CbrA is a specific, proton-driven L-histidine transporter.
"It is demonstrated that CbrA can bind and transport L-histidine. Transport is specific for L-histidine and probably driven by an electrochemical proton gradient."
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L-histidine does not modulate CbrA kinase activities in vitro, so the sensed signal is unknown.
"The lack of an effect of L-histidine leaves open the possibility that a yet to be identified intracellular metabolite is perceived by CbrA as a signal."
Role of the Transporter-Like Sensor Kinase CbrA in Histidine Uptake and Signal Transduction.
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The CbrA SSSF domain mediates histidine transport in P. fluorescens.
"Our combined data implicate the SSSF domain of CbrA in histidine transport and suggest that transport is coupled to signal transduction."
The CbrA-CbrB two-component regulatory system controls the utilization of multiple carbon and nitrogen sources in Pseudomonas aeruginosa.
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CbrA is a membrane sensor histidine kinase and CbrB its cognate response regulator.
"The cbrA and cbrB genes encode a sensor/histidine kinase (Mr 108 379, 983 residues) and a cognate response regulator (Mr 52 254, 478 residues) respectively."