Annotation inferences using phylogenetic trees
Gene Ontology annotation based on UniProtKB/Swiss-Prot Subcellular Location vocabulary mapping, accompanied by conservative changes to GO terms applied by UniProt
Combined Automated Annotation using Multiple IEA Methods.
The WD40 repeat PtdIns(3)P-binding protein EPG-6 regulates progression of omegasomes to autophagosomes.
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EPG-6 is a WD40 PROPPIN that binds PtdIns(3)P, binds ATG-2 directly, and with ATG-2 moves omegasomes on to autophagosomes.
"epg-6 and atg-2 regulate progression of omegasomes to autophagosomes, and their loss of function causes accumulation of enlarged early autophagic structures"
PI3P phosphatase activity is required for autophagosome maturation and autolysosome formation.
ATG-18 and EPG-6 are Both Required for Autophagy but Differentially Contribute to Lifespan Control in Caenorhabditis elegans.
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Both ATG-18 and EPG-6 are required for autophagic flux; epg-6 mutants are long-lived, unlike atg-18 mutants.
"we provide evidence that in the absence of either ATG-18 or EPG-6 autophagy was impaired"
Insights into autophagosome biogenesis from structural and biochemical analyses of the ATG2A-WIPI4 complex.
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Human WIPI4 binds one tip of ATG2A; the complex tethers PI3P-containing membranes to other membranes.
"WIPI4 binds to one of the tips, enabling the ATG2A-WIPI4 complex to tether a PI3P-containing vesicle to another PI3P-free vesicle"
KIF1A/UNC-104 Transports ATG-9 to Regulate Neurodevelopment and Autophagy at Synapses.
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epg-6 mutants, like atg-2 mutants, accumulate stalled autophagosomes in AIY neurons.
"all lesions in genes for late stages of autophagosome biogenesis and all known"
UniProt entry Q86MP3 (epg-6, C. elegans)
Autophagy-dependent ribosomal RNA degradation is essential for maintaining nucleotide homeostasis during C. elegans development.
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Loss of epg-6 suppresses lysosomal accumulation of rRNA and ribosomal proteins in rnst-2 mutants
"We found that mutation of atg-2 or epg-6 completely suppressed lysosomal accumulation of rRNA and ribosomal proteins in rnst-2(qx245) mutants"
WormBase gene description for epg-6 (worm)