Use of the ND evidence code for Gene Ontology (GO) terms
Annotation inferences using phylogenetic trees
Gene Ontology annotation based on UniProtKB/Swiss-Prot Subcellular Location vocabulary mapping, accompanied by conservative changes to GO terms applied by UniProt
The genome sequence of Schizosaccharomyces pombe.
Augmented annotation of the Schizosaccharomyces pombe genome reveals additional genes required for growth and viability.
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Identifies the locus as tam2 (transcripts altered in meiosis protein 2), a meiotically regulated transcript, and reports that its deletion is viable.
"While tam2 .Δ was viable, new21 was not"
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The transcript is among those differentially expressed during meiosis in fission yeast.
"Fourteen transcripts were differentially expressed during meiosis."
Regulation of COX Assembly and Function by Twin CX(9)C Proteins-Implications for Human Disease.
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CMC4 is a twin CX9C-family protein that localizes to the mitochondrial intermembrane space, imported via the Mia40/CHCHD4 redox relay.
"CMC4 is a CX9C family member that localizes to the mitochondrial IMS"
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Yeast CMC4 has eight cysteines, four forming the twin CX9C motif, and seven of the eight are conserved in the human ortholog.
"In yeast, CMC4 has eight cysteine residues, four of which comprise the twin CX9C motif."
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CMC4 is non-essential for respiration and its specific role is inferred from a physical interaction with the COX II assembly factor SCO1.
"The limited studies in yeast show that CMC4 knockdown produces no defect in respiration"
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A proximity/affinity study places human CMC4 with SCO1, suggesting a non-essential role in COX II sub-assembly.
"determined that CMC4 interacts with SCO1 in human cell cultures"