Gene Ontology annotation through association of InterPro records with GO terms
Manual transfer of experimentally-verified manual GO annotation data to orthologs by curator judgment of sequence similarity
Annotation inferences using phylogenetic trees
Gene Ontology annotation based on UniProtKB/Swiss-Prot Subcellular Location vocabulary mapping, accompanied by conservative changes to GO terms applied by UniProt
Gene Ontology annotation based on curation of immunofluorescence data
Electronic Gene Ontology annotations created by ARBA machine learning models
Combined Automated Annotation using Multiple IEA Methods
Characterization and chromosomal mapping of a novel human gene, ANKHZN.
The Rab5 effector Rabankyrin-5 regulates and coordinates different endocytic mechanisms.
Integral and associated lysosomal membrane proteins.
Proteomic analysis of exosomes from human neural stem cells by flow field-flow fractionation and nanoflow liquid chromatography-tandem mass spectrometry.
Large-scale proteomics and phosphoproteomics of urinary exosomes.
Network organization of the human autophagy system.
Rabankyrin-5 interacts with EHD1 and Vps26 to regulate endocytic trafficking and retromer function.
RhoD binds the Rab5 effector Rabankyrin-5 and has a role in trafficking of the platelet-derived growth factor receptor.
EHD3 Protein Is Required for Tubular Recycling Endosome Stabilization, and an Asparagine-Glutamic Acid Residue Pair within Its Eps15 Homology (EH) Domain Dictates Its Selective Binding to NPF Peptides.
GAPVD1 and ANKFY1 Mutations Implicate RAB5 Regulation in Nephrotic Syndrome.
RHOD binds effectors at the endosome membrane
ANKFY1 bridges ATG2A-mediated lipid transfer from endosomes to phagophores.
UniProtKB record for human ANKFY1/Rabankyrin-5
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UniProt summarizes ANKFY1 as a Rab5 effector involved in endosomal trafficking, macropinocytosis, receptor internalization, retromer-mediated transport, and podocyte migration.
ANKFY1 review notes for Proteostasis PN assessment
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The PN Cul3 substrate-receptor projection to GO:1990756 is not supported by ANKFY1-specific evidence.
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ANKFY1 is proteostasis-relevant through endosome-autophagosome lipid transfer rather than validated ubiquitin-like ligase-substrate adaptor activity.
Falcon deep research report for human ANKFY1
Proteostasis PN projected annotations report