DRG2 PN Consistency Notes
- Generated: 2026-06-18
- Project: PROTEOSTASIS
- Scope: PN consistency rereview against local AIGR review and available deep-research artifacts
- UniProt: P55039
- AIGR review status: COMPLETE
- Review batch: proteostasis-batch-2026-06-07c
- Batch change status: added
Source Files Checked
Deep Research Files
- No
*-deep-research*.md file found in this gene directory.
AIGR Review Snapshot
- Description: DRG2 (Developmentally-regulated GTP-binding protein 2) is a translational GTPase of the TRAFAC class, OBG-HflX-like superfamily (DRG/OBG GTPase family). It catalyzes hydrolysis of GTP to GDP, using Mg2+ as cofactor, and belongs to the conserved DRG family of ribosome-associated GTPases. DRG2 is stabilized by and functions together with its DFRP (DRG family regulatory protein) cofactor DFRP2/RWDD1, whose binding protects DRG2 from polyubiquitination and proteolytic degradation. DRG2 is a substrate of the JmjC oxygenase JMJD7, which catalyzes (3S)-lysyl hydroxylation at Lys-21; this modification is associated with RNA binding and a role in translation. DRG2 is found in both the cytoplasm and the nucleus and is most highly expressed in skeletal muscle, heart and kidney. Through its GTPase activity and ribosome/translation association it is implicated in regulation of protein synthesis, and at the cellular level it has been linked to cell proliferation and growth control.
- Existing/core annotation action counts: ACCEPT: 8; KEEP_AS_NON_CORE: 12; MARK_AS_OVER_ANNOTATED: 2
PN Consistency Summary
- Consistency: Review and notes are consistent with each other (DRG2 = TRAFAC/OBG-family translational GTPase; core MF GO:0003924 GTPase activity; JMJD7-hydroxylation/RNA-binding context; DFRP2/RWDD1 cofactor). They are NOT consistent with the PN placement: nothing in the review, notes, or GOA establishes DRG2 as a ribosome-associated quality-control / surveillance factor. The review even keeps the broad GO:0002181 cytoplasmic translation as non-core because "the specific regulatory role of human DRG2 in translation is not precisely defined."
- PN story / NEW pressure: Dossier projects GO:0006515 protein QC as
new_to_goa. No evidence (GOA has GO:0002181 + GO:0003924 only; no QC/RQC/rescue terms) supports DRG2 as an RQC factor. Asserting GO:0006515 would be an unsupported functional claim, not merely a broad umbrella — over-reaches. No defensible NEW term; if anything the gene is at most a generic ribosome-associated GTPase.
- Evidence alignment: Dossier provides no reference titles. Review anchors are PMID:29915238 (JMJD7/GTPase, VERIFIED) and PMID:7929244 (original cloning, VERIFIED) — both about GTPase identity, neither about RQC. Divergence: dossier RQC framing has no supporting citation.
- Verdict: GTPase biology is solid, but the PN RQC placement and GO:0006515 projection are unsupported for DRG2. Recommended edits: [MAP] do not project GO:0006515 (protein QC) to DRG2 — no RQC/surveillance evidence; GTPase activity (GO:0003924) is the supported core.
Full Consistency Review
- UniProt: P55039 · batch: proteostasis-batch-2026-06-07c · review status: COMPLETE
- PN placement:
Translation|Cytosolic translation|Ribosome-associated QC|other RQC processes ; PN-node mapping: type other RQC processes no_mapping; group Ribosome-associated QC → GO:0006515 protein QC (mapped, ok_for_propagation); class/branch context_only.
- Consistency: Review and notes are consistent with each other (DRG2 = TRAFAC/OBG-family translational GTPase; core MF GO:0003924 GTPase activity; JMJD7-hydroxylation/RNA-binding context; DFRP2/RWDD1 cofactor). They are NOT consistent with the PN placement: nothing in the review, notes, or GOA establishes DRG2 as a ribosome-associated quality-control / surveillance factor. The review even keeps the broad GO:0002181 cytoplasmic translation as non-core because "the specific regulatory role of human DRG2 in translation is not precisely defined."
- PN story / NEW pressure: Dossier projects GO:0006515 protein QC as
new_to_goa. No evidence (GOA has GO:0002181 + GO:0003924 only; no QC/RQC/rescue terms) supports DRG2 as an RQC factor. Asserting GO:0006515 would be an unsupported functional claim, not merely a broad umbrella — over-reaches. No defensible NEW term; if anything the gene is at most a generic ribosome-associated GTPase.
- Mapping strategy: This gene weakens the
Ribosome-associated QC group → GO:0006515 mapping: DRG2's membership in "other RQC processes" looks like taxonomic placement of a ribosome-associated GTPase rather than a demonstrated QC role. Recommend NOT projecting GO:0006515 onto DRG2 (no QC evidence).
- Evidence alignment: Dossier provides no reference titles. Review anchors are PMID:29915238 (JMJD7/GTPase, VERIFIED) and PMID:7929244 (original cloning, VERIFIED) — both about GTPase identity, neither about RQC. Divergence: dossier RQC framing has no supporting citation.
- Verdict: GTPase biology is solid, but the PN RQC placement and GO:0006515 projection are unsupported for DRG2. Recommended edits: [MAP] do not project GO:0006515 (protein QC) to DRG2 — no RQC/surveillance evidence; GTPase activity (GO:0003924) is the supported core.
PN Dossier Context
- review_batch: proteostasis-batch-2026-06-07c
- review_yaml: genes/human/DRG2/DRG2-ai-review.yaml
- PN workbook rows: 1
PN row 1: Translation | Cytosolic translation | Ribosome-associated QC | other RQC processes
- UniProt: P55039
- In branches: TR
- PN-node mapping records (path + ancestors):
- [type] Translation|Cytosolic translation|Ribosome-associated QC|other RQC processes
status=no_mapping scope= GO=[]
rationale: Reviewed as a broad PN category rather than a single GO class. The member genes span multiple activities, complexes, or contexts, so direct propagation from this node would overstate the shared biology.
- [group] Translation|Cytosolic translation|Ribosome-associated QC
status=mapped scope=ok_for_propagation_to_go GO=[GO:0006515 protein quality control for misfolded or incompletely synthesized proteins]
rationale: The PN ribosome-associated quality-control group covers surveillance and disposal of stalled or defective nascent-chain translation products. GO lacks a dedicated ribosome-associated QC term in the local cache, so the broader protein-quality-control process is the best supported target.
- [class] Translation|Cytosolic translation
status=context_only scope=too_broad_to_propagate GO=[GO:0002181 cytoplasmic translation]
rationale: The PN class Cytosolic translation is centered on the cytoplasmic translation apparatus and process, but it also houses supporting machinery such as ribosome biogenesis factors. The GO process term is a useful high-level label for the class, but propagating it to all members would over-annotate genes whose PN placement is through assembly or maturation context rather than core cytoplasmic translation.
- [branch] Translation
status=context_only scope=too_broad_to_propagate GO=[GO:0006412 translation]
rationale: The PN Translation branch is organized around the translation apparatus and immediately associated cotranslational quality-control systems. GO translation is the closest high-level process label, but the PN branch also contains adjacent machinery such as ribosome biogenesis and nascent-chain handling. Keeping this relationship is useful for interpretation, but it is too broad to project safely onto every member.
Projected GO annotations (1)
- GO:0006515 protein quality control for misfolded or incompletely synthesized proteins | scope=ok_for_propagation_to_go | goa_status=new_to_goa | from=Translation|Cytosolic translation|Ribosome-associated QC
Note
This file is generated from the current PROTEOSTASIS phase-1 dossier and local gene-review artifacts. Edit the source review, PN mapping, or dossier rather than this generated note when correcting the underlying curation.