Annotation inferences using phylogenetic trees
Gene Ontology annotation based on UniProtKB/Swiss-Prot keyword mapping
Gene Ontology annotation based on UniProtKB/Swiss-Prot Subcellular Location vocabulary mapping
Gene Ontology annotation based on curation of immunofluorescence data
Gene Ontology annotation based on curation of intracellular localizations of expressed fusion proteins
Electronic Gene Ontology annotations created by ARBA machine learning models
Crystal structure and mutagenic analysis of the inhibitor-of-apoptosis protein survivin.
Survivin and the inner centromere protein INCENP show similar cell-cycle localization and gene knockout phenotype.
Aurora-B phosphorylation in vitro identifies a residue of survivin that is essential for its localization and binding to inner centromere protein (INCENP) in vivo.
The chromosomal passenger complex is required for chromatin-induced microtubule stabilization and spindle assembly.
cIAP1 Localizes to the nuclear compartment and modulates the cell cycle.
Survivin mediates targeting of the chromosomal passenger complex to the centromere and midbody.
Molecular analysis of survivin isoforms - evidence that alternatively spliced variants do not play a role in mitosis.
Chromosome alignment and segregation regulated by ubiquitination of survivin.
Survivin - a protein with dual roles in mitosis and apoptosis.
Structure of a Survivin-Borealin-INCENP core complex reveals how chromosomal passengers travel together.
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1.4 A crystal structure of CPC regulatory core
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Survivin, borealin, and INCENP form tight three-helical bundle
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Complex creates composite surface essential for central spindle/midbody localization
A survivin-ran complex regulates spindle formation in tumor cells.
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Survivin associates with RAN-GTP
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Complex delivers TPX2 to microtubules for spindle assembly
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Function preferentially exploited in tumor cells
Molecular basis for phosphospecific recognition of histone H3 tails by Survivin paralogues at inner centromeres.
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Crystal structures of the human Survivin BIR domain bound to the H3T3ph histone tail peptide (PDB 3UEC) define how the CPC reads the phosphorylated histone code
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Mutation of Survivin residues contacting the H3 N-terminus lowers tail-binding affinity and reduces CPC recruitment to inner centromeres
Expression analysis suggests a potential cytoprotective role of Birc5 in the inner ear.
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Survivin expressed in cochlear cell types critical for hearing
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Noise exposure upregulates survivin expression
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Cytoprotective activity against gentamicin ototoxicity
An otoprotective role for the apoptosis inhibitor protein survivin.
Survivin monomer plays an essential role in apoptosis regulation.
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Survivin monomer interacts with XIAP and SMAC/DIABLO
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Monomer protects against caspase-dependent apoptosis through these interactions
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Only dimeric form enhances tubulin stability
Control of apoptosis and mitotic spindle checkpoint by survivin.
The Survivin-Crm1 interaction is essential for chromosomal passenger complex localization and function.
Cell death in leukemia: passenger protein regulation by topoisomerase inhibitors.
Hsp60 regulation of tumor cell apoptosis.
Mps1 phosphorylates Borealin to control Aurora B activity and chromosome alignment.
A single amino acid change converts Aurora-A into Aurora-B-like kinase in terms of partner specificity and cellular function.
Interaction of Beclin 1 with survivin regulates sensitivity of human glioma cells to TRAIL-induced apoptosis.
Phosphorylation of the CPC by Cdk1 promotes chromosome bi-orientation.
Acetylation directs survivin nuclear localization to repress STAT3 oncogenic activity.
Spatio-temporal composition of the mitotic Chromosomal Passenger Complex detected using in situ proximity ligation assay.
PAR, a protein involved in the cell cycle, is functionally related to chromosomal passenger proteins.
Toward an understanding of the protein interaction network of the human liver.
Impairment of glioma stem cell survival and growth by a novel inhibitor for Survivin-Ran protein complex.
Renal uptake of the antiapoptotic protein survivin is mediated by megalin at the apical membrane of the proximal tubule.
The GAR domain of GAS2L3 mediates binding to the chromosomal passenger complex and is required for localization of GAS2L3 to the constriction zone during abscission.
The Proapoptotic F-box Protein Fbxl7 Regulates Mitochondrial Function by Mediating the Ubiquitylation and Proteasomal Degradation of Survivin.
Aurora-C Interactions with Survivin and INCENP Reveal Shared and Distinct Features Compared with Aurora-B Chromosome Passenger Protein Complex.
Aurora kinase A regulates Survivin stability through targeting FBXL7 in gastric cancer drug resistance and prognosis.
Architecture of the human interactome defines protein communities and disease networks.
An AP-MS- and BioID-compatible MAC-tag enables comprehensive mapping of protein interactions and subcellular localizations.
A reference map of the human binary protein interactome.
Interactome Mapping Provides a Network of Neurodegenerative Disease Proteins and Uncovers Widespread Protein Aggregation in Affected Brains.
Dual proteome-scale networks reveal cell-specific remodeling of the human interactome.
Reactome pathway annotation
Spindle checkpoint signaling
Spindle checkpoint pathway
Spindle checkpoint signaling
Separase/cohesin cleavage
Sister chromatid separation
CDK1 phosphorylation of sororin
Deep research report on BIRC5