file:human/BBIP1/BBIP1-deep-research-falcon.md

Falcon deep research report for BBIP1

Gene Ontology annotation through association of InterPro records with GO terms

Annotation inferences using phylogenetic trees

Gene Ontology annotation based on UniProtKB/Swiss-Prot Subcellular Location vocabulary mapping, accompanied by conservative changes to GO terms applied by UniProt

GO_REF:0000052

Gene Ontology annotation based on curation of immunofluorescence data

PMID:19081074

A BBSome subunit links ciliogenesis, microtubule stability, and acetylation.

BBIP10 was identified as a BBSome subunit with ciliary localization and a requirement in ciliogenesis.
BBIP10 depletion alters cytoplasmic microtubule acetylation, which is restored by HDAC6 inhibition; the primary abstract also reports HDAC6 association.

"BBIP10 physically interacts with HDAC6."

PMID:22500027

Intrinsic protein-protein interaction-mediated and chaperonin-assisted sequential assembly of stable bardet-biedl syndrome protein complex, the BBSome.

BBIP10 joins the complex through BBS4; PCM1 co-association with BBIP10 depends on BBS4.

PMID:29039417

Protein interaction perturbation profiling at amino-acid resolution.

The BBS4–BBS18 interaction was mapped and perturbed by mutations in either partner, according to the original supplementary Figure 6 caption.

Reactome:R-HSA-5617815

BBSome binds RAB3IP

Reactome:R-HSA-5624125

Formation of the BBSome

Reactome:R-HSA-5624126

ARL6:GTP and the BBSome bind ciliary cargo

Reactome:R-HSA-5624127

ARL6:GTP and the BBSome target cargo to the primary cilium

Reactome:R-HSA-5624129

LZTFL1 binds the BBSome and prevents its traffic to the cilium

PMID:31951201

Structure of the human BBSome core complex.

The human six-subunit core structure places BBIP1 between BBS4 and BBS8, supporting a scaffold role within the assembled complex.