Gene Ontology annotation through association of InterPro records with GO terms

Manual transfer of experimentally-verified manual GO annotation data to orthologs by curator judgment of sequence similarity

Annotation inferences using phylogenetic trees

Gene Ontology annotation based on UniProtKB/Swiss-Prot Subcellular Location vocabulary mapping, accompanied by conservative changes to GO terms applied by UniProt

Gene Ontology annotation based on curation of immunofluorescence data

Electronic Gene Ontology annotations created by ARBA machine learning models

Combined Automated Annotation using Multiple IEA Methods

Phosphorylation of the linker for activation of T-cells by Itk promotes recruitment of Vav.

A quantitative protein interaction network for the ErbB receptors using protein microarrays.

SLP-76 mediates and maintains activation of the Tec family kinase ITK via the T cell antigen receptor-induced association between SLP-76 and ITK.

Selective targeting of ITK blocks multiple steps of HIV replication.

Identification of SH3 domain interaction partners of human FasL (CD178) by phage display screening.

Sequential phosphorylation of SLP-76 at tyrosine 173 is required for activation of T and mast cells.

Quantitative analysis of HSP90-client interactions reveals principles of substrate recognition.

Architecture of the human interactome defines protein communities and disease networks.

Histone Interaction Landscapes Visualized by Crosslinking Mass Spectrometry in Intact Cell Nuclei.

Oncogenic Mutations Rewire Signaling Pathways by Switching Protein Recruitment to Phosphotyrosine Sites.

Kinase Interaction Network Expands Functional and Disease Roles of Human Kinases.

Quantitative fragmentomics allow affinity mapping of interactomes.

A central chaperone-like role for 14-3-3 proteins in human cells.

Identification, cloning, and characterization of a novel human T-cell-specific tyrosine kinase located at the hematopoietin complex on chromosome 5q.

Evidence that the Wiskott-Aldrich syndrome protein may be involved in lymphoid cell signaling pathways.

Phosphorylation of PLC-gamma1

Recruitment of ITK to SLP-76

Phosphorylation of TEC kinases by p-SYK

Hydrolysis of PIP2 by PLCG

Autophosphorylation of BTK/ITK

Lck phosphorylates the activation loop tyrosine of the Itk kinase domain and activates Itk kinase activity.

Identification of phosphorylation sites within the SH3 domains of Tec family tyrosine kinases.

Tec kinase Itk forms membrane clusters specifically in the vicinity of recruiting receptors.

Inducible T cell tyrosine kinase regulates actin-dependent cytoskeletal events induced by the T cell antigen receptor.

Kinase-independent functions for Itk in TCR-induced regulation of Vav and the actin cytoskeleton.

Cyclophilin A regulates TCR signal strength in CD4+ T cells via a proline-directed conformational switch in Itk.

Girls homozygous for an IL-2-inducible T cell kinase mutation that leads to protein deficiency develop fatal EBV-associated lymphoproliferation.

A remote substrate docking mechanism for the tec family tyrosine kinases.

Itk tyrosine kinase substrate docking is mediated by a nonclassical SH2 domain surface of PLCgamma1.

Substrate recognition of PLCγ1 via a specific docking surface on Itk.

Identification of ITK deficiency as a novel genetic cause of idiopathic CD4+ T-cell lymphopenia.

The kinase ITK controls a Ca(2+)-mediated switch that balances T(H)17 and T(reg) cell differentiation.

Falcon deep research report for human ITK