Electronic Gene Ontology annotations created by ARBA machine learning models
TreeGrafter-generated GO annotations
Combined Automated Annotation using Multiple IEA Methods
UniProtKB entry Q88PU7 for Pseudomonas putida KT2440 mqo1
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UniProt annotates Q88PU7 as an MQO-family protein catalyzing (S)-malate oxidation with a quinone acceptor in the TCA cycle.
"Reaction=(S)-malate + a quinone = a quinol + oxaloacetate;"
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UniProt/HAMAP places mqo1 in the quinone-route TCA step from malate to oxaloacetate.
"oxaloacetate from (S)-malate (quinone route): step 1/1."
OpenScientist deep research report for Pseudomonas putida KT2440 mqo1
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The report supports mqo1 as a membrane-associated FAD-dependent malate:quinone oxidoreductase at the TCA/respiratory-chain interface.
"Mqo1 therefore functions simultaneously as a **TCA-cycle enzyme and a primary dehydrogenase of the respiratory chain**, structurally and functionally analogous to succinate dehydrogenase."
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The report notes that the mqo1-specific contribution remains unresolved because P. putida KT2440 has three MQO paralogs plus NAD-dependent Mdh.
"Paralog division of labor is unresolved."