Falcon deep research report for KCNQ1OT1
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Falcon supports KCNQ1OT1's core role as a cis-acting imprinted lncRNA that associates with the KCNQ1/KCNQ1OT1 domain and promotes local repressive chromatin, while treating miRNA-sponge disease models as non-core context-specific evidence.
"This report focuses on primary molecular roles of KCNQ1OT1 as a long non-coding RNA involved in genomic imprinting and chromatin regulation at the KCNQ1/KCNQ1OT1 imprinted domain."
Automatic Gene Ontology annotation of non-coding RNA sequences through association of Rfam records with GO terms
YY1-induced upregulation of lncRNA KCNQ1OT1 regulates angiotensin II-induced atrial fibrillation by modulating miR-384b/CACNA1C axis.
LncRNA KCNQ1OT1 promoted BMP2 expression to regulate osteogenic differentiation by sponging miRNA-214.
KCNQ1OT1 regulates osteogenic differentiation of hBMSC by miR-320a/Smad5 axis.