Gene Ontology annotation through association of InterPro records with GO terms
Annotation inferences using phylogenetic trees
Automatic assignment of GO terms using logical inference, based on on inter-ontology links
Outer membrane proteins responsible for the penetration of beta-lactams and quinolones in Pseudomonas aeruginosa.
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Chemically mutagenised latamoxef/quinolone-resistant PAO1 transductants had reduced amounts of four outer membrane proteins (C, D2, E1, E2) together, which lowered OM permeability.
"decreased amounts of outer membrane proteins C, D2, E1, and E2 lowered the"
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The authors conclude only that at least one of the four proteins acts as a porin for the drugs.
"The results suggested that at least one of the four proteins was"
Substrate specificity within a family of outer membrane carboxylate channels.
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Occ (OprD family) channels are the main route for small water-soluble molecules across the P. aeruginosa outer membrane.
"most of the water-soluble small molecules are thought to be taken up by members of the Outer membrane carboxylic acid channel (Occ) family"
Towards understanding single-channel characteristics of OccK8 purified from Pseudomonas aeruginosa.
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Native OccK8/OprE purified from P. aeruginosa forms channels in lipid bilayers with four conformations.
"OccK8 (also known as OprE), was investigated using single-channel"