FlyBase confirms the native 178-residue PD product. Sequence comparison maps it to full-length positions 275–452 with all three annotated iron ligands retained. The large deletion includes much of the catalytic scaffold; binding and enzyme activity cannot be inferred from the remaining ligand residues alone. Conversely, no direct assay of inactivity was identified. The three catalytic IEAs are removed and the external oxidoreductase claim is NPI: controlled human-to-Hn mapping identifies missing substrate and cofactor-binding architecture. Iron binding and both biological-process rows remain UNDECIDED; the external metabolic-process claim is UNC. Gene-level full-length Henna biology is not disputed.
PMID:10694386(https://pubmed.ncbi.nlm.nih.gov/10694386/) and PMID:12126628(https://pubmed.ncbi.nlm.nih.gov/12126628/) supply structural positions, checked against full-length Hn before interpreting the PD deletion. See the additional just human analysis and its positive control.
Falcon completed after its wrapper timed out. Its gene-level synthesis supports full-length Henna biology, including dietary tyrosine rescue and distinction from neuronal Trh; it does not resolve the native PD product. The manual synthesis supplies the exact-isoform structural analysis.